| 引用本文:曹岩，王勃，陈妹.地黄杜仲汤联合羟基脲对老年慢性粒细胞白血病患者的临床疗效及对预后的影响[J].世界中医药,2017,(02):. |
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| 地黄杜仲汤联合羟基脲对老年慢性粒细胞白血病患者的临床疗效及对预后的影响 |
| Clinical Efficacy of Rehmannia and Eucommia Bark Decoction Combined with Hydroxyurea on Elderly Patients with Chronic Myeloid Leukemia and Its Prognosis |
| 投稿时间：2016-08-15 |
| DOI：10.3969/j.issn.1673-7202.2017.02.011 |
| 中文关键词: 地黄杜仲汤 羟基脲 慢性粒细胞白血病 |
| English Keywords:Rehmannia and Eucommia Bark Decoction Hydroxyurea Chronic myeloid leukemia |
| 基金项目:辽宁省自然科学基金项目(编号:ln28123) |
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| 中文摘要: |
| 目的:探讨地黄杜仲汤联合羟基脲对老年慢性粒细胞白血病患者的临床疗效以及对预后产生的影响。方法:选取2012年3月至2015年7月在沈阳军区总医院接受治疗的老年慢性粒细胞白血病患者70例作为本次研究对象,采用随机数表法将他们分为治疗组和对照组各35例,对照组患者给予地黄杜仲汤治疗,治疗组患者给予地黄杜仲汤联合羟基脲治疗,比较2组患者治疗后的临床疗效、生存率以及不良反应发生情况。结果:治疗后,治疗组患者的总缓解率为94.28%高于对照组68.57%,2组比较差异有统计学意义(P<0.05);治疗组患者治疗后的≥6年生存率为80.00%,对照组为34.28%,治疗组高于对照组,2组比较差异有统计学意义(P<0.05);治疗组患者治疗后出现恶心呕吐、白细胞低、肾功能异常以及肝功能异常等不良反应的发生率明显低于对照组患者,2组患者进行比较,差异有统计学意义(P<0.05)。结论:地黄杜仲汤联合羟基脲治疗老年慢性粒细胞白血病临床效果显著,降低不良反应,延长患者的生存期。 |
| English Summary: |
| To evaluate the clinical efficacy of Rehmannia and Eucommia Bark Decoction combined hydroxyurea on elderly patients with chronic myeloid leukemia and the prognosis.Methods:A total of 70 cases of elderly patients with chronic myeloid leukemia from March 2012 to July 2015 in our hospital，using a random number table method，were divided into two groups，35 cases in the control group (given Rehmannia and Eucommia Bark Decoction)，and 35 cases in the observation group (given Rehmannia and Eucommia Bark Decoction combined hydroxyurea therapy).The clinical efficacy，survival and adverse events of the two groups were observed after treatment.Results:After treatment，the overall response rate of the observation group was 94.28%，higher than the control group′s 68.57%，the difference was significant (P<0.05); the observation group patients′ survival rate after six-year was 80.00%，higher than the control group′s 34.28%，the difference was significant (P<0.05); the adverse events in observation group including nausea and vomiting after treatment，low white blood cells，the incidence of renal dysfunction and liver dysfunction were significantly lower than patients in the control group (P<0.05).Conclusion:Rehmannia and Eucommia Bark Decoction combined with hydroxyurea treatment has significant clinical effect in elderly patients with chronic myeloid leukemia by reducing side effects and prolonging the survival of patients. |
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