Clinical curative effects and advantages of Bushen Shenggu Granules in the treatment of postmenopausal osteoporosis of kidney deficiency and blood stasis type were observed, for providing references for clinical treatment of postmenopausal osteoporosis. Methods:A total number of 112 patients with postmenopausal osteoporosis of kidney deficiency and blood stasis type who met the inclusive criteria and had complete follow-up data were included and randomly divided into the treatment group (56 cases of oral Bushen Shenggu Granules) and the control group (56 cases of oral Gail, D). Improvement of clinical symptoms and signs and changes in bone mineral density (BMD), serum levels of estradiol (E2), bone alkaline phosphatase (BALP), n-terminal osteocalcin (N-MID) of the two groups before and after the treatment were observed. Results:The total efficacy of the treatment group was 67.86% compared with that of the control group of 50.0%, showing statistically significant difference (P<0.05). The curative effect of the treatment group was superior to that of the control group. Syndromes curative effect of treatment group was 89.29% compared with that of the control group of 28.57%, with significant difference (P<0.05). After treatment, there were no changes in serum E2 of the control group after treatment, while serum E2 elevated in the treatment group (P<0.05). BMD in the control group and the treatment group after treatment showed statistical difference (P<0.05). Bone density increased significantly and BALP and N-MID lowered in the treatment group after treatment with a statistically significant difference (P<0.05), and the treatment group was better than that of the control group. Conclusion:Bushen Shenggu Granules for Postmenopausal Osteoporosis of kidney deficiency and blood stasis type has good effect on improving clinical symptoms and may increase BMD, regulate Estrogen levels, neurotransmitters and bone metabolism. It regulates hypothalamus-pituitary-ovarian axis function, promote ovarian hormones, adjust neurotransmitter, in order to reduce bone absorption and promote bone formation and metabolism.