| 引用本文:王丽丽，房经武，王金国.补肾生骨颗粒对肾虚血瘀型绝经后骨质疏松症BMD、E2、BALP、N-MID的影响[J].世界中医药,2017,(02):. |
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| 补肾生骨颗粒对肾虚血瘀型绝经后骨质疏松症BMD、E2、BALP、N-MID的影响 |
| Effect of Bushen Shenggu Granules on BMD, Serum E2, BALP, N-MID of Patients Postmenopausal Osteoporosis of Kidney Deficiency and Blood Stasis Type |
| 投稿时间：2015-11-12 |
| DOI：10.3969/j.issn.1673-7202.2017.02.014 |
| 中文关键词: 补肾生骨颗粒 肾虚血瘀 绝经后骨质疏松症 临床研究 |
| English Keywords:Bushen Shenggu Granules Kidney deficiency and blood stasis type Postmenopausal osteoporosis Clinical research |
| 基金项目:山东省中医药科技发展计划项目（编号：2013ZDZK-143） |
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| 中文摘要: |
| 目的：观察补肾生骨颗粒治疗肾虚血瘀型绝经后骨质疏松症(Postmenopausal Osteoporosis，PMOP）的临床疗效和优势，为临床治疗绝经后骨质疏松症提供更多的途径。方法：选择符合纳入标准的门诊或住院治疗获得完整随访资料的肾虚血瘀型绝经后骨质疏松症患者112例，采用随机对照法，分治疗组(口服补肾生骨颗粒)和对照组（口服钙尔奇D)，每组各56例。观察治疗前后2组患者的临床症状和体征好转情况，以及治疗前后2组患者骨密度（BMD），血清雌二醇（E2）、骨碱性磷酸酶（BALP）、N端骨钙素(N-MID)的变化，比较治疗后2组指标改善情况。结果：1)临床疗效：治疗组总有效率67.86%与对照组总有效率50.0%比较，差异有统计学意义（P<0.05），疗效优于对照组。2）中医证候疗效：治疗组的证候疗效89.29%与对照组28.57%比较，差异有统计学意义（P<0.05），疗效优于对照组。3）治疗后，治疗组E2升高(P<0.05)；2组BMD治疗后比较，差异有统计学意义（P<0.05），治疗组骨密度提高明显；2组BALP、N-MID治疗后均降低，2组比较差异有统计学意义（P<0.05），治疗组优于对照组。结论：补肾生骨颗粒能够改善肾虚血瘀型绝经后骨质疏松症的临床症状，增加BMD，对患者的雌激素水平、神经递质及骨代谢指标有一定的调节作用，可通过调节患者下丘脑-垂体-卵巢轴功能，增加卵巢激素分泌水平，调节神经递质，从而减少骨吸收，促进骨形成，改善骨代谢。 |
| English Summary: |
| Clinical curative effects and advantages of Bushen Shenggu Granules in the treatment of postmenopausal osteoporosis of kidney deficiency and blood stasis type were observed, for providing references for clinical treatment of postmenopausal osteoporosis. Methods:A total number of 112 patients with postmenopausal osteoporosis of kidney deficiency and blood stasis type who met the inclusive criteria and had complete follow-up data were included and randomly divided into the treatment group (56 cases of oral Bushen Shenggu Granules) and the control group (56 cases of oral Gail, D). Improvement of clinical symptoms and signs and changes in bone mineral density (BMD), serum levels of estradiol (E2), bone alkaline phosphatase (BALP), n-terminal osteocalcin (N-MID) of the two groups before and after the treatment were observed. Results:The total efficacy of the treatment group was 67.86% compared with that of the control group of 50.0%, showing statistically significant difference (P<0.05). The curative effect of the treatment group was superior to that of the control group. Syndromes curative effect of treatment group was 89.29% compared with that of the control group of 28.57%, with significant difference (P<0.05). After treatment, there were no changes in serum E2 of the control group after treatment, while serum E2 elevated in the treatment group (P<0.05). BMD in the control group and the treatment group after treatment showed statistical difference (P<0.05). Bone density increased significantly and BALP and N-MID lowered in the treatment group after treatment with a statistically significant difference (P<0.05), and the treatment group was better than that of the control group. Conclusion:Bushen Shenggu Granules for Postmenopausal Osteoporosis of kidney deficiency and blood stasis type has good effect on improving clinical symptoms and may increase BMD, regulate Estrogen levels, neurotransmitters and bone metabolism. It regulates hypothalamus-pituitary-ovarian axis function, promote ovarian hormones, adjust neurotransmitter, in order to reduce bone absorption and promote bone formation and metabolism. |
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