| 引用本文:吉文龙，杨君，邢海龙.参苓健脾胃颗粒对慢性萎缩性胃炎患者胃泌素及免疫功能影响[J].世界中医药,2017,(02):. |
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| 参苓健脾胃颗粒对慢性萎缩性胃炎患者胃泌素及免疫功能影响 |
| Effect of Shenlingjianpiwei Granule on Gastrin and Immune Function in Patients with Chronic Atrophic Gastritis |
| 投稿时间：2016-07-13 |
| DOI：10.3969/j.issn.1673-7202.2017.02.016 |
| 中文关键词: 参苓健脾胃颗粒 慢性萎缩性胃炎 胃泌素 免疫功能 腹痛 |
| English Keywords:Shenlingjianpiwei granule Chronic atrophic gastritis Gastrin Immune function Abdominal pain |
| 基金项目:江苏省卫生厅基金项目（编号：js281223） |
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| 中文摘要: |
| 目的:探讨参苓健脾胃颗粒对慢性萎缩性胃炎患者胃泌素及免疫功能的影响。方法:慢性萎缩性胃炎患者86例，随机分为对照组和2组，各43例。对照组在常规药物治疗的基础上进行叶酸片治疗，观察组在对照组基础上加以参苓健脾胃颗粒进行治疗。比较2组患者治疗前后胃泌素水平、sIL-2R水平、CD4+T、CD8+T、CD4+T/CD8+T水平及治疗效果。结果:治疗后，研究组胃泌素水平(7.65±0.89)较对照组(5.12±0.53)明显升高，差异有统计学意义（P<0.05）。治疗后观察组sIL-2R水平(300.89±31.68)较对照组(383.21±38.92)明显降低，差异有统计学意义（P<0.05）。治疗后观察组CD4+T、CD4+T/CD8+T水平较对照组明显提高，差异有统计学意义（P<0.05）；观察组CD8+T水平明显低于对照组，差异有统计学意义（P<0.05）。观察组总有效率95.35%高于对照组74.42%，差异有统计学意义（P<0.05）。结论:参苓健脾胃颗粒治疗慢性萎缩性胃炎患者疗效佳，能够通过改善患者胃泌素水平及免疫功能提高治疗效果。 |
| English Summary: |
| To explore the effect of Shenlingjianpiwei granule on gastrin and immune function in patients with chronic atrophic gastritis.Methods All 86 patients with chronic atrophic gastritis were randomly divided into a control group and an observation group，43 cases in each.Patients in the control group were given Folic Acid Tablets combined with convention drug therapy for treatment，whereas those in the observation group were treated with Shenlingjianpiwei granule combined with conventional therapy.The levels of gastrin，sIL-2R，CD4+T，CD8+T，CD4+T/CD8+T and therapeutic effect in the two groups were compared before and after treatment.Results After treatment，gastrin level in the observation group was (7.65±0.89)，significantly increased compared with that in the control group (5.12±0.53)，and the difference was statistically significant (P<0.05).After treatment，sIL-2R level in the observation group was (300.89±31.68)，significantly reduced than that of the control group (383.21 ± 38.92)，and the difference was statistically significant (P<0.05).After treatment，levels of CD4+T and CD4+T/CD8+T in the observation group were significantly increased than that of the control group，and the difference was statistically significant (P<0.05).CD8+T level in the observation group was much lower than that in the control group，and the difference was statistically significant (P<0.05).The total effective rate in the observation group was 95.35%，higher than the 74.42% in the control group，and the difference was statistically significant (P<0.05).Conclusion For patients with chronic atrophic gastritis，Shenlingjianpiwei granule is with satisfactory curative effect，which can improve the patients′ gastrin and immune function thus boost the therapeutic effect. |
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