世界中医药

目的:益气化瘀中药方对非介入治疗不稳定型心绞痛(UA)患者血管内皮的保护作用。方法:以入院病例号为编号,根据随机数字表,将160例UA(气虚血瘀型)患者随机分成2组,每组80例。对照组按照常规西医治疗方法,观察组同时配合中药益气化瘀,用药1月后比较患者中医症状改善情况,并对患者血管内皮功能指标、血小板活化指标、心功能指标进行测定。并对患者进行24个月的随访工作,记录心血管事件发生情况。结果:治疗后,观察组总有效率96.2%,优于对照组60.0%,P<0.05;治疗后,2组患者NO均升高,高于治疗前(P<0.05),观察组NO高于对照组NO水平(P<0.05);2组患者ET-1均降低,低于治疗前(P<0.05),观察组ET-1低于对照组ET-1水平(P<0.05);治疗后,2组Pad T和Pgd T均降低,观察组降低幅度大于对照组(P<0.05);治疗前后,2组患者TXB2变化不明显(P>0.05);治疗前后比较,2组BNP和LVEF变化无统计学意义(P>0.05);治疗后,观察组BNP和LVEF与对照组比较无统计学意义(P>0.05);随访24个月,2组各失访2人,2组间心血管事件发生率差异有统计学意义(P<0.05)。结论:益气化瘀中药可有效治疗气虚血瘀型UA,对UA患者冠状动脉内皮功能有一定改善作用,并可抑制血小板活性,从而改善UA患者预后情况。

English Summary:

To investigate the protective effects of Qi-replenishing and Stasis-resolving Formula on vascular endothelium in patients with unstable angina pectoris (UA). Methods:A total of 160 cases of UA (Qi deficiency and blood stasis type) were randomly divided into two groups, with 80 cases in each group. The control group received conventional western medicine treatment, while the observation group was treated with Chinese medicine of Qi-replenishing and Stasis-resolving Formula. The treatment lasted for one month. And Chinese medicine syndrome, vascular endothelial function, platelet activation index and cardiac function index were measured. The patients were followed up for 24 months to record the occurrence of cardiovascular events. Results:After treatment, the total effective rate of the observation group was 96.2%, significantly higher than control group′s 60%, P<0.05; after treatment, NO of two groups increased (P<0.05), NO of the observation group received significantly better results than control group (P<0.05); ET-1 in two groups reduced significantly after the treatment (P<0.05), the ET-1 ET-1 levels of observation group were lower than the control group (P<0.05); after treatment, Pad T and Pgd T reduced in the both two groups, while the observation group was lower than the control group (P<0.05); TXB2 in the two group did not change significantly after the treatment (P>0.05); after treatment, BNP and LVEF changes in the two groups were not statistically significant (P>0.05); after treatment, there were no significant differences of BNP and LVEF in the two groups (P>0.05); after 24 months′ follow-up, two patients in both group dropped, and there was a significant difference in cardiovascular events between the two groups (P<0.05). Conclusion:Qi-replenishing and Stasis-resolving Formula can be effective in the treatment of qi deficiency and blood stasis type UA, and there is significant improvement in UA patients′ coronary artery endothelial function, and it can inhibit platelet activity, thereby improving the prognosis of patients.

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