To evaluate the effect of treating advanced gastric cancer with Shenba Kangliu Liquid combined with chemotherapy. Methods:Forty cases of advanced gastric cancer were randomly divided into the treatment group (Shenba Kangliu Liquid + chemotherapy) and the control group (chemotherapy). Patients in the control group were only received FOLFOX4, while Shenba Kangliu Liquid (30 ml/d, d1-14) was added for the first week for patients in the treatment group combined with chemotherapy as well and Shenba Kangliu Liquid was stopped in the second week. Two weeks were set as one course. Results:1) The effective rate of recent tumor objective efficacy in the treatment group was superior to that of the control group, showing no statistical significance (P>0.05). 2) KPS scores were significantly better in the treatment group than those in the control group. There was statistically significant difference (P<0.01). 3) Changes in weight gain and patients′ stability of the treatment group were better than those in the control group, showing statistical significance (P<0.05). 4) The bone marrow suppression of the treatment group was also lower than that of the control group (P<0.01). 5) The gastrointestinal reaction of the treatment group was obviously lower with fewer side effects than that of the control group, which indicated statistical significance (P<0.05). Conclusion:Treating advanced gastric cancer with Shenba Kangliu Liquid combined with chemotherapy may improve quality of life and reduce side effects from chemotherapy.