There are few applications of Chinese medicine powder in animal experiments.This study is to compare the differences between the Chinese medicine powder and decoction in oncology experiment in vitro and vivo.Methods:Shuangshen granules power,decoction and alcohol extract were prepared based on the literature and characters of the medicinals.In vitro experiment,the effects of Shuangshen granules power alcohol extract and traditional decoction on lewis lung cancer cells were compared; in vivo experiment,two dosage forms were compared in efficacy on lung metastasis inhibition in C57BL/6 tumor-bearing mice.Results:The powder had more obvious effects on growth/migration inhibitory and apoptosis promotion,which also showed better effects on early tumor-growth inhibition than decoction,but not on lung metastasis.Conclusion:there is great difference between Chinese medicine power and decoction in oncology routine experiment,therefore more research should be done with it.