世界中医药

目的：观察使用大柴胡汤加减联合生长抑素治疗急性胰腺炎前后，血中降钙素原（PCT）及C-反应蛋白的变化情况，从而探讨大柴胡汤对急性胰腺炎患者血中降钙素原及C-反应蛋白影响，并观察其临床疗效。方法：选取本院50例急性胰腺炎患者，随机分为2组，对照组15例使用生长抑素等常规药物治疗；治疗组35例，在对照组治疗的基础上，给予大柴胡汤加减经胃管注药。2组患者在确诊后即刻及治疗1 d、3 d、7 d时抽取静脉血，分别检测血降钙素原及C-反应蛋白(CRP)含量，同时检测2组血常规白细胞计数及血淀粉酶检查。并分析2组生存率、重症患者肠鸣音恢复时间以及住院时间。结果：大柴胡汤加减联合生长抑素治疗组在PCT、CRP、白细胞计数及血淀粉酶方面与对照组相比，差异有统计学意义(P<0.05)；在首次主动排便时间、住院时间之间差异存在明显统计学意义(P<0.01)。结论：大柴胡汤加减联合生长抑素可明显降低血PCT及CRP，调节胰酶分泌、抑制炎性反应因子，在治疗急性胰腺炎中有协同作用，是治疗急性胰腺炎的有效方法之一。

English Summary:

To observe the change of procalcitonin (PCT) and C-reactive protein (CRP) in patients with acute pancreatitis after the treatment of Dachengqi decoction combined with somatostatin, then discussing the clinical curative effect of Dachengqi decoction on acute pancreatitis. Methods:Fifty cases of patients with acute pancreatitis in our hospital were randomly divided into two groups, with 15 cases given conventional treatment (eg:octreotide) in control group，and 30 cases given Dachengqi decoction by gastric tube in treatment group on the basis of the control group treatment. After treatment of 1 d, 3 d, 7 d, patients in two groups were immediately drew blood and detected the level of PCT and CRP. At the same time, white blood cell count and blood amylase examination were counted and conduced to analyze the two groups’ survival times, first time defecation, and hospitallization duration. Results:After treatment, the differences of PCT,CRP, WBC count and blood amylase between the two groups have statistical significance (P<0.05). In terms of first time of defecation, hospitalization stay, the two groups have obvious differences (P<0.01). Conclusion:Dachengqi decoction combined with somatostatin can obviously decrease PCT and CRP, regulate the function of endocrine of pancreas, and inhibit inflammatory cytokines. It can function cohesively with somatostatin, and be used as one of the methods in treating acute pancreatitis.

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