| 引用本文:李赛，许筱颖，郭霞珍，肖燕兰.逍遥丸、归脾丸治疗老年期阈下抑郁症疗效观察[J].世界中医药,2017,(03):. |
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| 逍遥丸、归脾丸治疗老年期阈下抑郁症疗效观察 |
| Clinical Observation on the Efficacy of Xiaoyaowan and Guipiwan in Treating Sub-threshold Depression of Older People |
| 投稿时间：2017-01-20 |
| DOI：10.3969/j.issn.1673-7202.2017.03.022 |
| 中文关键词: 逍遥丸 归脾丸 老年期阈下抑郁症 治未病 |
| English Keywords:Xiaoyaowan Guipiwan Older people sub-threshold depression Preventive treatment of disease |
| 基金项目:北京市朝阳区协同创新项目(编号CYXC1515);国家自然科学基金青年项目(编号:30901887);国家自然科学基金面上项目(编号:81573840) |
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| 中文摘要: |
| 目的:初步探索逍遥丸、归脾丸对肝郁脾虚型、心脾两虚型老年期阈下抑郁症的影响。方法:本研究采用前瞻性研究方法收集样本,通过DSM-IV、HAMD-17、CES-D以及中医辨证筛选出肝郁脾虚型、心脾两虚型老年期阈下抑郁症患者,并随机选取30例纳入空白对照组,将余下样本根据证型分类分别纳入归脾丸组和逍遥丸组,每组30例,最后观察归脾丸、逍遥丸对老年期阈下抑郁症的疗效。结果:1)12周末归脾丸组和逍遥丸组的总有效率均明显高于对照组,而归脾丸组与逍遥丸组的总有效率比较,差异无统计学意义(P>0.05)。2)归脾丸、逍遥丸从干预4周末开始,才开始与同时期对照组HAMD-17评分比较,差异有统计学意义(P<0.05),同时期归脾丸组与逍遥丸组之间评分变化比较,差异无统计学意义(P>0.05)。结论:1)逍遥丸和归脾丸能够治疗老年期阈下抑郁症,从第4周开始有明显疗效。2)用归脾丸、逍遥丸治疗期阈下抑郁症,能够预防老年期抑郁症,符合中医“治未病”理论。 |
| English Summary: |
| To observe the clinical effect of Xiaoyaowan and Guipiwan in treating sub-threshold depression of liver qi stagnation and spleen deficiency and heart-spleen dual deficiency syndrome in older people. Methods:Using prospective research method to collect sample and using DSM-IV, HAMD-17, CES-D and TCM syndrome differentiation method to screen out sub-threshold depression older people with liver qi stagnation and spleen deficiency and heart-spleen dual deficiency syndrome. Then randomly selected 30 people into the blank control group, and divided other cases in to two groups(Guipiwan group and Xiaoyaowan group) according to the two types, with 30 cases in each. Compare the results after treatment. Results:1) After 12 weeks, the total effective rate of Guipiwan group and Xiaoyaowan group are significantly higher than that of the blank control group, while no difference was found between Guipiwan group and Xiaoyaowan group (P>0.05). 2) After 4 weeks, the HAMD-17 score of Guipiwan group and Xiaoyaowan group began to show significant difference with the blank control group(P<0.05), while no difference was found between the two groups. Conclusion:1) Guipiwan and Xiaoyaowan can be used in treating sub-threshold depression in older people, and the effect started to show from the fourth week of treatment. 2) Guipiwan and Xiaoyaowan can also prevent senile dementia, which can be used in the prevention of the disease. |
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