世界中医药

目的：观察健脾疏肝降脂方对单纯性肥胖患者治疗前后患者临床疗效及相关实验室指标的影响。方法：采用双盲随机对照原则，分为治疗组34例、对照组34例。治疗组采用健脾疏肝降脂方口服治疗，对照组采用安慰剂治疗，疗程28 d。观察治疗前后的临床疗效及对患者身体质量指数(BMI)、中医症候评分、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、瘦素（Leptin）、脂联素（Adiponectin）的影响情况。结果：2组患者临床总有效率差异有统计学意义（P<0.05）;治疗前后2组患者BMI指数、中医症候量表、TC、TG、LDL-C、HDL-C、Leptin差异有统计学意义（P<0.05）；2组Adiponectin差异无统计学意义（P>0.05）。结论：健脾疏肝降脂方治疗肝郁脾虚证所致单纯性肥胖具有较好疗效，主要体现在减低BMI指数、降低血TC、TG、LDL-C、Leptin；升高HDL-C方面。

English Summary:

To evaluate the efficacy, clinical characteristics and relevant laboratory variables of JianPi ShuGan JiangZhi Formula in the treatment of simple obesity. Methods:In our prospective, double-blind, randomized, controlled clinical trial, a total of 68 patients with simple obesity were randomly divided into JianPi ShuGan JiangZhi Formula group (the experimental group, given JianPi ShuGan JiangZhi Formula treatment) and placebo group (the control group). The treatment lasted for 28 days. The clinical response, body mass index(BMI), TCM syndrome score, serum level of total cholesterol (TC), glycerin three greases (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C), and the expression of leptin/adiponectin after treatment were observed in both groups. Results:After 28 days’ treatment, the clinical efficacy and all the laboratory indexes (except of adiponectin) were superior in the experimental group to those in the control group(P<0.05). There was no statistical difference in the level of adiponectin expression between the two groups(P>0.05). Conclusion:JianPi ShuGan JiangZhi Formula is effective for simple obesity caused by liver stagnation and spleen deficiency. It can improve the BMI index, reduce serum level of TC, TG,LDL-C and Leptin expression, and increase serum level of HDL-C.

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