Chronic renal failure (CRF) is a major clinical symptom composed of a variety of chronic kidney diseases caused by persistent renal damages or losses. This paper analyzed of Lyu Renhe’s treatment of CRF cases as well as the prescription principles. Methods:The clinical records of 49 patients with CRF were retrospectively studied. Using the statistical method of association rules analysis, the prescription principles of Lyu Renhe were explored. Results:The total effective rate was 81.6%. Through statistics, induction and analysis, it was found that the combination of Milkvetch Root and Angelica, Nutgrass Galingale Rhizome and Lindera Root, Tree Peony Root Bark and Salvia Root, Orange Fruit and Immature Orange Fruit, Dried Tangerine Peel and Pinellia Tuber, Cape Jasmine Fruit and Virgate Wormwood, Salvia Root, Peach Seed, Safflower, Prince’s-Feather Fruit, Cibot Rhizome, Himalayan Teasel Root, Medicinal Cyathula Root, Perilla Stem, Citron Fruit and Salvia Root were commonly seen. Conclusion:Lyu Renhe has rich experience in treatment of CRF, as well as flexible and unique prescription. The treatment is clear and effective, which reflects the characteristics and advantages of Chinese medicine in treatment of CRF.