| 引用本文:吕新会，李军，史玮，武佶，李颖.冠心病合并非瓣膜性房颤患者228例中医证候要素分布特征[J].世界中医药,2017,(03):. |
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| 冠心病合并非瓣膜性房颤患者228例中医证候要素分布特征 |
| Analysis of Traditional Chinese Medicine Syndrome Distribution on 228 Cases with Coronary Heart Disease Combined with Non-valvular Atrial Fibrillation |
| 投稿时间：2016-04-17 |
| DOI：10.3969/j.issn.1673-7202.2017.03.046 |
| 中文关键词: 非瓣膜性房颤 冠心病 证候要素 |
| English Keywords:Non-valvular atrial fibrillation Coronary heart disease Syndromes |
| 基金项目:国家中医药管理局行业专项“基于临床科研信息共享系统的真实世界冠心病诊疗方案研究”（编号：201207001）；十二五重点领域研究专项“不能进行血运重建的冠心病应用中西医综合治疗的疗效评价研究”（编号：ZZ0808005） |
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| 中文摘要: |
| 目的：分析冠心病合并非瓣膜性房颤患者中医证候要素分布特征及与血栓风险评分（CHA2DS2-VASc）、出血风险（HAS-BLED）评分的关系。方法：收集广安门医院2012年7月至2015年7月228例冠心病合并非瓣膜性房颤住院患者的临床资料，并进行统计分析。结果：冠心病合并非瓣膜性房颤患者证素分布情况从高到低依次为血瘀>气虚>痰浊>阴虚>阳虚>热蕴>湿邪>水饮>气滞>血虚>寒凝。单一证素较少，大多由2个证素至4个证素组合而成。3种不同房颤的证素分布未见明显差异（P>0.05）。结果显示阴虚与CHA2DS2-VASc评分相关系数为0.149，P=0.024<0.05，有统计学意义；血虚与HAS-BLED评分相关系数为0.134，P=0.043<0.05，有统计学意义。其余证素与评分间P>0.05，无统计学意义。结论：冠心病合并非瓣膜性房颤患者证素分布以血瘀、气虚、痰浊、阴虚为主，多为虚实夹杂；3种不同房颤的证素分布差异无统计学意义；阴虚证患者血栓风险较高。 |
| English Summary: |
| To analyze the distribution of traditional Chinese medicine (TCM) syndromes among patients with coronary heart disease (CHD) combined with non-valvular atrial fibrillation (AF). Furthermore, to research their correlation with CHA2DS2-VAS and HAS-BLED scores.Methods:A total of 228 cases with CHD combined with non-valvular AF admitted by Guang’anmen Hospital from July 2012 to July 2015 were included. Clinical data of these patients were collected to analyze.Results:The frequent sequence of TCM syndromes among patients are blood stasis, qi deficiency, turbid phlegm, yin deficiency, yang deficiency, heat deposition, dampness, excessive fluid, qi stagnation, blood deficiency, and cold coagulation. Commonly seen are mixed syndromes of two to four, while single syndrome are seldom seen. The distribution of different TCM syndromes have no significant difference in paroxysmal AF, persistent AF and permanent AF (P>0.05). The results showed that yin deficiency and CHA2DS2-VASc score have correlation (r=0.149, P=0.024<0.05), and blood deficiency correlates to HAS-BLED scores (r=0.134, P=0.043<0.05). There is no statistical significance between other TCM syndromes and CHA2DS2-VASc and HAS-BLED scores (P>0.05).Conclusion:TCM syndromes of patients with CHD combine non-valvular AF mainly include blood stasis, qi deficiency, turbid phlegm, and yin deficiency, especially deficiency complicated with excess syndrome. The correlation between TCM syndrome and three types of AF have no significant difference. However, patients with yin deficiency have higher thrombus risk. |
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