| 引用本文:张立敏，安红梅.中药复方抗氧化治疗阿尔茨海默病[J].世界中医药,2017,(03):. |
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| 中药复方抗氧化治疗阿尔茨海默病 |
| Anti-oxidative Chinese Herbal Formulas in Treatment of Alzheimer’s Disease |
| 投稿时间：2016-06-01 |
| DOI：10.3969/j.issn.1673-7202.2017.03.056 |
| 中文关键词: 阿尔茨海默病 β-淀粉样蛋白 氧化应激 中药复方 抗氧化 |
| English Keywords:Alzheimer’s disease β-amyloid Oxidative stress Chinese herbal formula Anti-oxidation |
| 基金项目:国家自然科学基金项目（编号：81470195）；上海市卫生和计划生育委员会中医药科研基金项目(编号：2014XZ005A)；上海市中医药事业发展三年行动计划项目（编号：ZY3-JSFC-2-2003） |
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| 中文摘要: |
| 阿尔茨海默病（Alzheimer’s Disease，AD）是一种常见的神经退行性疾病，β-淀粉样蛋白（β-amyloid，Aβ）诱导的氧化应激是其重要的发病因素。Aβ通过与细胞表面的晚期糖基化终产物受体（Receptor for Advanced Glycationendproducts，RAGE）结合诱发氧化应激损伤；也可以通过Aβ的第35位氨基酸残基蛋氨酸（Met-35）诱导氧化应激损伤；还可以插入脂质双分子层，催化自由基的产生，导致氧化应激损伤，参与AD发病。地黄饮子、左归丸、黄连解毒汤等经典方，补肾益智汤、黄精地龙方、还脑益聪方等当代验方可抑制自由基的生成，保护神经元免受氧化应激的伤害，从而防治AD。 |
| English Summary: |
| Alzheimer’s disease (AD) is a common neurodegenerative disease and its pathogenesis is related to oxidative stress induced by β-amyloid (Aβ). Aβ induces oxidative stress through three pathways,namely 1) binding to the receptor of advanced glycation end products (RAGE) on cell surface; 2) inducing oxidative stress by the 35th methionine residue (Met-35) of Aβ; 3) catalyzing the synthesis of free radical by inserting into lipid bilayer. Some classic herbal formulas,such as Di-Huang-Yin-Zi Decoction,Zuo-Gui Pill and Huang-Lian-Jie-Du Decoction,as well as contemporary empirical herbal formulas including Bu-Shen-Yi-Zhi Decoction,Huang-Jing-Di-Long Decoction and Huan-Nao-Yi-Cong Decoction,can inhibit generation of free radical,protect neurons from oxidative stress damage and thus contribute to AD prevention and treatment. |
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