世界中医药

目的：探讨中药保留灌肠方法治疗慢性盆腔炎对患者的临床治疗效果和细胞炎性反应因子水平的影响。方法：选取本院收治的慢性盆腔炎患者110例，随机分为治疗组与对照组各55例，2组均采用常规抗炎治疗，治疗组在此基础上加用中药保留灌肠进行治疗。2组均在1个疗程后进行临床疗效、细胞炎性反应因子水平、复发情况及生活质量评价。结果：2组在年龄、病程、病情等一般资料比较，差异无统计学意义（P>0.05）。治疗组总有效率（90.91%）显著高于对照组（61.82%），差异有统计学意义（P<0.05）；治疗后治疗组血清TNF-α与治疗前相比显著减少（P<0.05），而IL-2、IL-10较治疗前显著增加（P<0.05）；而对照组以上三项指标治疗前后比较无统计学意义（P>0.05）；治疗后治疗组血清肿瘤坏死因子-α（TNF-α）、白介素-2（IL-2）、白介素-10（IL-10）与对照组比较差异有统计学意义（P<0.05）。生活质量评分比较，除医疗依赖性2组无显著差别外，治疗组各项评分均优于对照组，差异有统计学意义（P<0.05）。治疗组半年复发率显著低于对照组（P<0.05）。结论：中药保留灌肠治疗慢性盆腔炎患者的临床效果显著，能够有效改善炎性反应，降低半年疾病发病率，有效改善患者预后，安全可靠，具有重要的研究意义。

English Summary:

To investigate the effect of retention enema of traditional Chinese medicine on the treatment of chronic pelvic inflammatory disease and the level of inflammatory factors.Methods:Selecting 110 cases of chronic pelvic inflammatory disease，all of them were randomly divided into an observation group and a control group，55 cases in each.Both of the groups were treated with conventional anti-inflammatory therapy，and the observation group was treated with extra retention enema of traditional Chinese medicine.After a course of treatment，the groups were evaluated from clinical efficacy，inflammatory factors levels，recurrence and quality of life.Result：There was no significant difference in the age，course of disease，disease and other general information between the two groups (P>0.05).The total effective rate of the observation group (90.91%) was significantly higher than that of the control group (61.82%)，and the difference was statistically significant (P<0.05); after treatment，the serum levels of NF-α of the observation group significantly reduced (P<0.05)，and IL-2，IL-10 increased significantly，comparing with before treatment (P<0.05)，while the above three indexes of control group before and after treatment had no statistically significance (P>0.05); after treatment，there was statistical significance in observation group’s serum TNF，IL-2 and IL-10 level，comparing with the control group (P<0.05); as to the quality of life score comparison，except that there was no obvious difference in medicine dependence，all other scores of the observation group were better than those in the control group，and the difference was statistically significant (P<0.05).The recurrence rate in 6 months of the observation group was significantly lower than that in the control group (P<0.05).Conclusion:TCM retention enema has significant clinical effect in chronic pelvic inflammation patients.It can effectively improve the inflammatory reaction，reduce the recurrence rate for the first half of the year and improve the prognosis of patients，safe and reliable，with significant research meaning.

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