To observe the clinical effect of integrative Chinese and western medicine in the treatment of burn scar hyperplasia. Methods:A total of 110 cases of burn scar hyperplasia patients admitted in our hospital from September 2014 to September 2016 year were randomly divided into two groups. The control group received Fuchunsan II treatment， and the observation group were given pressure therapy and laser irradiation therapy based on the medication of the control group. Compare curative effect between the two groups after treatment. Results:The two groups’ VSS score had no statistical difference before treatment(P>0.05). After treatment， the observation group’s VSS score was (2.2± 0.7)， significantly lower than that of the control group (P<0.05). The observation group’s mild pigmentation ratio was 70.9%， significantly higher than that of the control group (3.6%) and lower than the control group (P>0.05). The efficiency rate of the observation group was 83.6%， significantly higher than that of the control group (P<0.05). Conclusion:Using coated Danxiong Scar Coating combined with scar pressure therapy in burn patients after laser irradiation treatment can effectively control the formation of scar tissue and reduce the degree of pigmentation. Its prognosis is good， and it is worthy of clinical promotion.