世界中医药

作者	单位
傅兰清1，胡亚俊1，郭小娟2	1 荆州市中心医院（华中科技大学同济医学院附属荆州医院）骨科，荆州，434020； 2 湖北省中药现代化工程技术研究中心，武汉，430223

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中文摘要:

目的：观察健脾生血颗粒治疗骨科择期手术患者贫血的临床疗效及安全性。方法：将120例患者随机分为2组。治疗组给予健脾生血颗粒治疗，对照组给予琥珀酸亚铁片治疗。比较2组患者治疗前，治疗1周、2周、3周、4周、手术当日及术后1 d、1个月，术后2个月，术后3个月的血红蛋白及血清铁蛋白变化，评价2组术前等待时间及术后血清铁蛋白复常时间，药品不良反应和预后情况。结果：1）2组治疗后血红蛋白水平均有显著改善（P<0.05），且治疗组在第2、第3、第4周指标改善情况显著优于对照组，差异有统计学意义（P<0.05）；2）与对照组相比，治疗组可将择期手术等待时间缩短6.35 d，2组比较存在统计学意义（P<0.05）；3）与对照组相比，治疗组可将血清铁蛋白复常时间缩短0.85个月，两者比较存在统计学意义（P<0.05）；4）治疗组药品不良反应发生率明显低于对照组（P<0.05）。结论：健脾生血颗粒治疗骨科术前贫血疗效显著，可显著缩短术前等待时间与术后血清铁蛋白复常时间，且安全性佳。

English Summary:

To observe the clinical effect and safety of the treatment of Jianpi Shengxue granule in selective orthopaedic surgical patients with preoperative anaemia. Methods:A total of 120 cases were randomly divided into two groups with 60 in each. The treatment group was treated with JianpiShengxue granule， while the control group was treated with iron succinate. The levels of hemoglobin(Hb) and serum ferritin(SF) before treatment， after 1w， 2w， 3w， 4w， sugary day， and after 1 d， 1 m， 2 m， 3 m were recorded. To compare the recovery duration， adverse reactions and prognosis of the two groups. Results:After treatment， Hb levels in both groups were improved， and the treatment group was better than the control group after 2w， 3w， and 4w of treatment (P<0.05). Besides， the waiting time of surgery of the treatment group was shortened by 6.35 days (P<0.05). In addition， SF recovery duration in the treatment group was shortened by 0.85 months (P<0.05). Also， the incidence of adverse reactions in the treatment group was significantly lower than that of the control group（P<0.05). Conclusion:Jianpi Shengxue granule can treat selective orthopaedic surgical patients with anaemia safely and effectively. It can shorten preoperative waiting time for surgery and SF level recovery time.

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