| 引用本文:高翠敏.小儿热速清颗粒联合抗生素治疗小儿急性化脓性扁桃体炎的临床观察[J].世界中医药,2017,(04):. |
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| 小儿热速清颗粒联合抗生素治疗小儿急性化脓性扁桃体炎的临床观察 |
| Clinical Observation of Children Resuqing Granules Combined with Antibiotic in the Treatment of Acute Suppurative Tonsillitis |
| 投稿时间：2016-11-23 |
| DOI：10.3969/j.issn.1673-7202.2017.04.028 |
| 中文关键词: 小儿热速清颗粒 小儿急性化脓性扁桃体炎 临床疗效 |
| English Keywords:Children resuqing Granules Children acute suppurative tonsillitis Clinical efficacy |
| 基金项目:国家自然科学基金项目(编号:300760296)——扶正解表法调节上呼吸微生物生态防治感染性疾病的作用机制 |
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| 中文摘要: |
| 目的:观察小儿热速清口服液联合抗生素治疗小儿急性化脓性扁桃体炎的临床疗效。方法:选取2013年1月至2015年12月在北京市大兴区人民医院儿科就诊的急性化脓性扁桃体炎患儿300例，按照随机数字表法均分为观察组和对照组，每组150例。对照组患儿给予阿奇霉素干混悬剂;观察组患儿除了对照组治疗的基础上，给予小儿热速清颗粒进行治疗，2组患儿治疗疗程均为5 d。观察2组患儿退热时间、咽痛消失时间，疗效情况，白细胞计数变化，C反应蛋白水平，治疗前后T淋巴细胞及不良反应发生情况。结果:观察组患儿平均退热时间和咽痛消失时间观察组均短于对照组，疗效明显优于对照组，2组治疗后白细胞计数和C反应蛋白水平均降低，观察组明显低于对照组，差异均有统计学意义(P<0.05);治疗前后2组患儿CD4+/CD3+、CD8+/CD3+、CD4+/CD8+比较差异均有统计学意义(P<0.05)。观察组治疗前后CD8+/CD3+比较，差异无统计学意义(P>0.05)。2组患儿不良反应发生率比较，差异无统计学意义(P>0.05)。结论:在抗生素的基础上加用小儿热速清颗粒治疗小儿急性化脓性扁桃体炎的疗效值得肯定，安全性好，适合临床推广运用。 |
| English Summary: |
| To observe the efficacy and safety of Children resuqing granules combined with antibiotic in the treatment of acute suppurative tonsillitis.Methods:A total of 300 children with acute suppurative tonsillitis were randomly divided into control group and observation group.Control group was treated with azithromycin;based on the treatment of control group，observation group was treated with Children resuqing granules，3~4 times a day.The treatment course was 5 d.The clinic data was observed，including clinical efficacy，average cooling time and throat disappear time，WBC，CRP level，and CD4+/CD3+，CD4+/CD8+and CD8+/CD3+in vivo before and after treatment and incidence of adverse reactions in 2 groups.Results:The total effective rate in observation group was significantly higher than control group，average cooling time and throat disappear time were significantly shorter than control group(P<0.05).After treatment，WBC and CRP level were significantly lower than before，and observation group was lower than control group;CD4+/CD3+was significantly higher than before，and observation group was higher than control group;CD4+/CD8+in observation group was significantly higher than before and control group，CD8+/CD3+in control group was significantly higher than before(P<0.05);however，there were no significant differences in the CD8+/CD3+in observation group before and after treatment，and incidence of adverse reactions between 2 groups (P>0.05).Conclusion:Based on the treatment of Children resuqing granules has better efficacy and safety in the treatment of acute suppurative tonsillitis. |
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