| 引用本文:郭杨志1，杜娟2，李向民1，冯兴中1，郭伟3.黄连对糖尿病肾病大鼠肾脏NF-κB及PPAR-γ表达的影响[J].世界中医药,2017,(04):. |
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| 黄连对糖尿病肾病大鼠肾脏NF-κB及PPAR-γ表达的影响 |
| Effect of Coptis Chinensis on Expression of NF-κB and PPAR-γ in Kidney of Diabetic Nephropathy Rats |
| 投稿时间：2016-11-28 |
| DOI：10.3969/j.issn.1673-7202.2017.04.044 |
| 中文关键词: 糖尿病肾病 黄连 NF-κB PPAR-γ |
| English Keywords:Diabetic nephropathy Coptis Chinensis NF-κB PPAR-γ |
| 基金项目:北京市中医药科技项目青年研究项目(编号:QN2014-08);北京世纪坛医院青年博士基金(编号:2016QB07);国家中医重点专科建设项目 |
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| 中文摘要: |
| 目的:观察黄连对糖尿病肾病大鼠肾脏病理、肾小球NF-κB及PPAR-γ mRNA的影响。方法:采用高脂饮食结合腹腔注射链脲佐菌素方法建立糖尿病SD大鼠模型，随机分为模型组、厄贝沙坦组［31.25 mg/（kg·d)］、黄连低、中、高剂量组［相当于人黄连饮片用量的83 mg/（kg·d）、500 mg/（kg·d）、1000 mg/（kg·d)］，每组8只，另取8只正常大鼠作为对照，给药12周后，检测各组大鼠肾小球NF-κB及PPAR-γ mRNA表达水平及肾脏病理变化。结果:黄连各剂量组可显著降低大鼠肾脏NF-κB表达(P<0.05)，黄连高剂量组及厄贝沙坦组可显著增强大鼠肾脏PPAR-γ mRNA表达(P<0.05)，各用药组均有一定改善大鼠肾脏病变的作用。结论:黄连具有降低糖尿病肾病大鼠肾脏NF-κB表达及增强PPAR-γ mRNA表达的作用，可缓解肾脏病变。 |
| English Summary: |
| To investigate the effect of Coptis Chinensis on NF-κB， PPAR-γ and pathological changes of kidney in STZ-induced Diabetic Rats. Methods:Diabetic model in SD rats were established by intravenous injection of STZ combined with high-fat chow feeding. The models were randomly divided into a model group， an Irbesartan group ［31.25 mg/(kg·d)］， and Coptis Chinensis low-， mid-， and high-dose ［equal with Coptis Chinensis used in human:83 mg/(kg·d)，500 mg/(kg·d)，1000 mg/(kg·d)］ groups (n=8 each)， other 8 SD rats were selected as normal group. After 12 consecutive weeks of administration， the expression of NF-κB and PPAR-γ in kidney was detected， and the pathological changes of kidney were observed. Results:The Coptis Chinensis groups decreased the expression of NF-κB (P<0.05); The Coptis Chinensis mid-dose group and Irbesartan group increased the expression of PPAR-γ(P<0.05); In all the Coptis Chinensis groups and Irbesartan group， pathological changes of kidney on STZ-induced diabetic rats were alleviated. Conclusion:Coptis Chinensis can decrease the expression of NF-κB， increase the expression of PPAR-γ and alleviate the pathological changes of kidney in STZ-induced Diabetic Rats. |
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