The wild resources of Polygonum multiflorum are scarce，and are unable to meet market demand.Methods:Here we collected its distribution samples in the main producing areas and applied them to Global geographic information system for medicinal plant(GMPGIS)to analyze the optimum producing area of Polygonum multiflorum worldwide.The GMPGIS used seven ecological factors to predict the suitable ecological region and potential artificial cultivation area.Results:Finally，we got the total optimum area of 780.7×104 km2 for Polygonum multiflorum cultivation，distributed in 69 countries and regions.The main countries are China，USA，Brazil，Ukraine，France and so on.The main producing areas in China are Yun Nan，Si Chuan，Guang Xi，Hu Nan，Hu Bei，Gui Zhou etc.Polygonum multiflorum from different areas show different quality.Conclusion:Through GMPGIS，we got a wide range of ecological suitability of Polygonum multiflorum in the world.It provides scientific basis for the artificial cultivation of this Chinese material medica.