| To observe the clinical effect of Shenghua decoction for treatment of atonic postpartum hemorrhage (PHH) and its effect on stress indices and protein levels of RhoA, Rho kinaseⅠ(ROCKⅠ) and Rho kinaseⅡ (ROCKⅡ). Methods:A total of 100 cases with PHH were randomly divided into experimental group and control group, with 50 cases in each group. The control group was treated with carbetocin, while the experimental group was treated with shenghua decoction on the basis of control group. The hemostatic time, amount of bleeding, postpartum hemoglobin (Hb) level, blood pressure and stress indices, RhoA protein, Rho protein and ROCK protein levels and adverse reactions were observed and compared between the two groups. Results:After treatment, hemostatic time, postpartum hemorrhage, the decrease of Hb, levels of E, NE, R and Ang II of the experimental group were lower than those of the control group (P<0.01); SBP and DBP of two groups before and after treatment have no significant difference(P>0.05); RhoA, ROCK I and ROCK II protein levels of 2 groups after treatment were significantly higher after treatment (P<0.05 or P<0.01), but there was no significant difference between two groups (P>0.05). Conclusion:Use Shenghua decoction combined with carbetocin in treating PHH panteins have significant effect and no obvious adverse reactions, which can shorten hemostatic time, reduce postpartum hemorrhage and stress reaction, enhance the function of patients with uterine smooth muscle contraction. |
