| 引用本文:王福琴，刘政，李成伟，戚明，刘永娟，张海燕，张淑青.基于TCM-PRO-PHD量表的芪苈强心胶囊改善老年COPD致PHD稳定期患者生活质量的临床观察[J].世界中医药,2017,(05):. |
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| 基于TCM-PRO-PHD量表的芪苈强心胶囊改善老年COPD致PHD稳定期患者生活质量的临床观察 |
| Improvement of Life Quality by Qiliqiangxin Capsule on Elderly PHD Patients in Stable Phase Caused by COPD：A Clinical Observation Based on TCM-PRO-PHD Scale |
| 投稿时间：2016-06-15 |
| DOI：10.3969/j.issn.1673-7202.2017.05.013 |
| 中文关键词: 芪苈强心胶囊 慢性阻塞性肺疾病致肺心病 基于患者报告结局的肺心病中医主症量表 生活质量 |
| English Keywords:Qiliqiangxin capsule PHD caused by COPD TCM-PRO-PHD scale Life quality |
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| 中文摘要: |
| 目的：观察芪苈强心胶囊改善老年慢性阻塞性肺疾病(COPD)致肺源性心脏病(PHD)稳定期患者生活质量的临床疗效。方法：采用前瞻性研究方法，选择德州市中医院收治的符合研究标准的老年COPD致PHD稳定期患者98例，按随机数字表法分为对照组和治疗组；对照组给予西药常规治疗，治疗组在常规西药治疗基础上加用芪苈强心胶囊，2组均连续治疗6个月。通过自制基于患者报告结局的肺心病中医主症（TCM-PR0-PHD）量表和肺功能检测(CAT、FEV1/预测值)、明尼苏达生活量表(LHFQ)和6分钟步行实验(6MWT)对患者的生活质量进行比较，并比较2组间患者在临床疗效、急性加重次数和不良反应发生情况方面的差异性。结果：在显效率和总有效率方面治疗组显著优于对照组（P<0.05）；治疗组患者的急性加重次数明显少于对照组（P<0.05）；治疗组在TCM-PR0-PHD评分、CAT、FEV1/预测值、LHFQ及6MWT明显优于对照组（P<0.05）；通过TCM-PR0-PHD评分进一步比较发现，治疗组在改善患者咳嗽、乏力、胸闷、易感冒、水肿、心慌、纳差、汗出多等方面存在显著优势。结论：芪苈强心胶囊对改善COPD致PHD稳定期老年患者的生活质量有积极意义。 |
| English Summary: |
| To observe improvement of life quality by Qiliqiangxin capsule on elderly phase pulmonary heart disease(PHD) patients in stable phase caused by chronic obstructive pulmonary disease(COPD).Methods:A prospective study was conducted，98 patients who met with the study criteria in Dezhou hospital of TCM were enrolled，and they were randomly divided into a control group and a treatment group; the control group was treated by conventional western medicine treatment，and the treatment group was treated with extra Qiliqiangxin capsule，both for six months.Compare the quality of life by self-made traditional Chinese medicine-patient reported outcomes-pulmonary heart disease(TCM-PR0-PHD) scale，pulmonary function test，Minnesota life scale and 6-minute walk test，as well as the curative effect，the number of acute exacerbation and adverse reactions between the two groups.Results:Total effective rate and efficiency rate in treatment group was higher than those of the control group（P<0.05）.Patients in treatment group with acute exacerbation significantly was less than those in the other group（P<0.05）.TCM-PR0-PHD scale，CAT、 FEV1/predicted value、LHFQ and 6MWT in treatment group were superior to the control group（P<0.05）.Cough，fatigue，chest tightness，being easy to get cold，edema，flustered，poor appetite，over sweat were markedly improved in treatment group found by means of TCM-PRO-PHD scale.Conclusion:Qiliqiangxin capsule is positive in improvement of life quality on elderly PHD patients in stable phase caused by COPD. |
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