基于TCM-PRO-PHD量表的芪苈强心胶囊改善老年COPD致PHD稳定期患者生活质量的临床观察
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Improvement of Life Quality by Qiliqiangxin Capsule on Elderly PHD Patients in Stable Phase Caused by COPD:A Clinical Observation Based on TCM-PRO-PHD Scale
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    摘要:

    目的:观察芪苈强心胶囊改善老年慢性阻塞性肺疾病(COPD)致肺源性心脏病(PHD)稳定期患者生活质量的临床疗效。方法:采用前瞻性研究方法,选择德州市中医院收治的符合研究标准的老年COPD致PHD稳定期患者98例,按随机数字表法分为对照组和治疗组;对照组给予西药常规治疗,治疗组在常规西药治疗基础上加用芪苈强心胶囊,2组均连续治疗6个月。通过自制基于患者报告结局的肺心病中医主症(TCM-PR0-PHD)量表和肺功能检测(CAT、FEV1/预测值)、明尼苏达生活量表(LHFQ)和6分钟步行实验(6MWT)对患者的生活质量进行比较,并比较2组间患者在临床疗效、急性加重次数和不良反应发生情况方面的差异性。结果:在显效率和总有效率方面治疗组显著优于对照组(P<0.05);治疗组患者的急性加重次数明显少于对照组(P<0.05);治疗组在TCM-PR0-PHD评分、CAT、FEV1/预测值、LHFQ及6MWT明显优于对照组(P<0.05);通过TCM-PR0-PHD评分进一步比较发现,治疗组在改善患者咳嗽、乏力、胸闷、易感冒、水肿、心慌、纳差、汗出多等方面存在显著优势。结论:芪苈强心胶囊对改善COPD致PHD稳定期老年患者的生活质量有积极意义。

    Abstract:

    To observe improvement of life quality by Qiliqiangxin capsule on elderly phase pulmonary heart disease(PHD) patients in stable phase caused by chronic obstructive pulmonary disease(COPD).Methods:A prospective study was conducted,98 patients who met with the study criteria in Dezhou hospital of TCM were enrolled,and they were randomly divided into a control group and a treatment group; the control group was treated by conventional western medicine treatment,and the treatment group was treated with extra Qiliqiangxin capsule,both for six months.Compare the quality of life by self-made traditional Chinese medicine-patient reported outcomes-pulmonary heart disease(TCM-PR0-PHD) scale,pulmonary function test,Minnesota life scale and 6-minute walk test,as well as the curative effect,the number of acute exacerbation and adverse reactions between the two groups.Results:Total effective rate and efficiency rate in treatment group was higher than those of the control group(P<0.05).Patients in treatment group with acute exacerbation significantly was less than those in the other group(P<0.05).TCM-PR0-PHD scale,CAT、 FEV1/predicted value、LHFQ and 6MWT in treatment group were superior to the control group(P<0.05).Cough,fatigue,chest tightness,being easy to get cold,edema,flustered,poor appetite,over sweat were markedly improved in treatment group found by means of TCM-PRO-PHD scale.Conclusion:Qiliqiangxin capsule is positive in improvement of life quality on elderly PHD patients in stable phase caused by COPD.

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王福琴,刘政,李成伟,戚明,刘永娟,张海燕,张淑青.基于TCM-PRO-PHD量表的芪苈强心胶囊改善老年COPD致PHD稳定期患者生活质量的临床观察[J].世界中医药,2017,(05).

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  • 收稿日期:2016-06-15
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  • 在线发布日期: 2017-05-26
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