To observe the curative effect of Children Resuqing granules in treating pediatric fever induced by acute upper respiratory infection. Methods:To select 400 patients with upper acute respiratory infection in our hospital, who are admitted from January 2015 to December 2015. To randomly divide them in to two groups, with 182 cases in the control group and 215 cases in the observation group. The control group was given Pseudoephedrine Hydrochloride and Dextromethorphan Hydrobromide Drops and the observation group was given children Resuming granules. After 3 days of treatment, observe the clinical efficacy, body temperature restoring time and adverse reactions. Results:Total effective rate of Children Eesuqing group is 92.8% compared with 64.9% of the control group, which has statistically significant(P<0.05). No adverse reactions were found. Besides, the treatment group recovers faster than the control group, with significant difference. Conclusion:Children Resuming granule has obvious effect in treating acute upper respiratory infection with little adverse reactions, which is worthy of clinical promotion.