To observe the effect of Yiqi Tongbi decoction on cardiac function and vascular endothelial function in patients with myocardial infarction. Methods:A total of 84 cases with myocardial infarction in our department from May 2015 to October were divided into two groups, with 42 in each. Cases in control group were given routine treatment and cases in the observation were given Yiqi Tongbi decoction based on routine treatment. Changes of cardiac function, myocardial reperfusion injury and vascular endothelial function of the two groups were compared after treatment. Results:After treatment, LVEF and E/A of the observation group was higher than that of the control group, LVEDD was lower than that of the control group, and the difference was statistically significant (P<0.05). Besides, CRP, CK, CK-MB of the observation group was lower than that of the control group (P<0.05). NO of the observation group was higher than that of the control group, and ET-1 was lower than that of the control group, and the difference was statistically significant (P<0.05). Conclusion:Yiqi Tongbi decoction can significantly improve cardiac function and vascular endothelial function in patients with myocardial infarction, reduce the reperfusion injury of patients with less adverse reaction, which is worthy of being promoted.