To investigate effects of electrical stimulation on hand Jueyin channel combined with xingnaojing injection on cerebral coma and nerve function. Methods: All 100 cases of cerebral coma patients admitted in our hospital from September 2014 to June 2016 were randomly divided into an observation group of 50 cases and a control group of 50 cases. The control group were treated with Xingnaojing injection, and the observation group with extra hand Jueyin electrical stimulation treatment. The course of treatment in the two groups was 10 d. The therapeutic effects of the two groups were compared, as well as the changes of GCS score, NIHSS score, 5-HT, DA and Ach before and after treatment. Results: The total efficiency of the observation group (88.00%) was higher than that of the control group (72.00%) (P<0.05); the GCS scores of the two groups increased after treatment (P<0.05); the GCS score of the observation group after treatment was higher than that of the control group (P<0.05); the NIHSS scores of the two groups after treatment decreased (P<0.05); the NIHSS score of the observation group after treatment was lower than that of control group (P<0.05); the two groups before and after 5-HT treatment had no significant difference (P>0.05); two groups' DA and Ach increased after treatment (P<0.05); the observation group's DA and Ach after treatment was higher than that of the control group (P<0.05). Conclusion: The electrical stimulation on hand Jueyin channel combined with xingnaojing injection have obvious curative effect on cerebral coma, and can improve the neurological function of the patients, showing important clinical significance.