To investigate the effect of salvia miltiorrhiza injection combined with heparin on fetal growth restriction (FGR) and on fetal umbilical artery blood flow and maternal blood rheology. Methods:All 88 patients with FGR who were in our hospital from August 2014 to April 2016 were randomly divided into an observation group (n=44) and a control group (n=44). The control group were treated with salvia miltiorrhiza combined with dextran amino acid, the observation group salvia miltiorrhiza combined with low molecular weight heparin sodium, and 1 course was 7 days, 2 groups treated for 3 courses. The fetal growth and umbilical artery blood flow were compared between 2 groups before and after treatment; the blood coagulation and hemorheology indexes of 2 groups were detected and compared; the newborns and perinatal complications of 2 groups were statistically analyzed. Results:The growth of fetal biparietal diameter, head circumference, abdominal circumference and femur length, uterine height in observation group was significantly faster than that of the control group (P<0.01). The total effective rate of the observation group was 93.18%, which was higher than that ,77.27%, of the control group (P<0.05). After treatment, the PI, RI and S/D in observation group were lower than those before treatment and control group (P<0.01), and in control group, only S/D decreased (P<0.01). Compared with before treatment, PT and APTT were significantly prolonged, FIB, D-D, whole blood low shear viscosity, plasma viscosity and hematocrit were significantly decreased in 2 groups (P<0.05 or P<0.01). Compared with the control group, PT in observation group prolonged, FIB, D-D, whole blood low shear viscosity, plasma viscosity and hematocrit decreased (P<0.05 or P<0.01). Compared with the control group, the gestational age of the neonates was prolonged, the birth weight, body length and 1 min Apgar score were significantly higher in observation group (P<0.05 or P<0.01). Conclusion:Salvia miltiorrhiza injection combined with heparin can improve fetal growth, improve fetal umbilical blood flow and maternal rheological parameters in the middle and late pregnancy. The curative effect is definite and has certain clinical application value.