To discuss the clinical effect on skin pruritus in Maintenance hemodialysis (MHD)patients with external treatment of Traditional Chinese Medicine (TCM )by means of “nourishing and activating blood, removing dampness and turbidity”.Methods: A total of 64 cases of MHD patients with skin pruritus treated during January 2015 to June 2016 were selected. They were randomly divided into treatment group and control group with 32 cases in each. The control group was given low-phosphorus diet with basic treatment and Hemodialysis three times a week. On the basis of the control group, external treatment was added to another group upon sysndrome differentiation with traditional Chinese herbs or prescriptions functioning as nourishing and activating blood, and removing dampness and turbid The total clinical effective rate, skin pruritus score and blood biochemical data were observed before and after the treatment. Results: The total clinical effective rate of treatment group was 93.7%, and control group was 68.7%. There was statistically significant difference between the two groups (P<0.01); The comparison of skin pruritus score and blood biochemical data in the two groups: the skin pruritus score, levels of blood urea nitrogen and serum phosphorus of the treatment group were significantly decreased(P<0.05); there was also significant reduction compared with the control group(P<0.05); The two groups underwent obviously changes in the levels of serum creatinine、Serum calcium and serum parathyroid hormone (P<0.05). Conclusion: With the strategy of “nourishing and activating blood, removing dampness and turbid”based upon TCM syndrome differentiation, not only can skin pruritus be relieved from patients with MHD, but also levels of Blood urea nitrogen and Serum phosphorus are effectively reduced, which is worthy of clinical application.