世界中医药

目的:探讨益气活血通络法联合参芪复方颗粒治疗糖尿病周围神经病变疗效及安全性。方法：选择本院于2014年1月-2016年1月收治的糖尿病周围神经病变患者60例纳入本研究，随机分为2组，每组30例。对照组于控制血糖、调脂等常规西医治疗基础上给予益气活血通络法治疗，1剂/d，连续服用8周；观察组于对照组基础上联合参芪复方颗粒治疗，比较2组中医证候积分、疗效及不良反应发生率。结果：治疗后观察组中医症候评分显著低于对照组（P<0.05）；且观察组治疗后总有效率为21例（70.0%），显著低于对照组16例（53.3%），差异有统计学意义（P<0.05）；2组不良反应发生率比较差异无统计学意义（P>0.05）。结论：益气活血通络法联合参芪复方颗粒治疗糖尿病周围神经病变疗效较佳，改善临床症状效果明显，且不良反应发生率，临床应用安全。

English Summary:

To investigate the effects and safety of Yiqi Huoxue Tongluo method (decoction serving as replenishing qi, activating blood circulation and collaterals) combined with Shenqi compound granule in the treatment of diabetic peripheral neuropathy. Methods: Select 60 cases of patients with diabetic peripheral neuropathy admitted to our hospital from January 2014 to January 2016 and randomly divided them into 2 groups with 30 cases in each. The control group was given conventional western therapy( including glucose control and lipid regulation) in combination with Yiqi Huoxue Tongluo decoction: 1 dose per day, for 8 continuous weeks. The observation group received Shenqi compound granules treatment based on the control group. Comparison of TCM syndrome, curative effect and incidence of adverse reaction was made between the two groups. Results: TCM symptoms of the observation group was significantly lower than that of the control group (P<0.05); the observation group was obviously higher than the control group in terms of the total effective rate (21 cases, 70% vs. 16 cases, 53.3%). The differences were statistically significant (P<0.05). There was no statistical significance (P>0.05) regarding the incidence of adverse reaction by comparing the wo groups. Conclusion: Yiqi Huoxue Tongluo method combined with Shenqi compound granule in the treatment of diabetic peripheral neuropathy proves to be favorable and safe in terms of cuative effect and relief of clinical symtoms with low or no adverse reaction.

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