| 引用本文:马文苑，裴中美，丁奇龙，邢婷，葛爱雷，刘琴，殷素娟，吴晓燕，刘建成.参附注射液穴位注射对慢性充血性心力衰竭患者NT-proBNP和6MWD的影响[J].世界中医药,2017,(05):. |
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| 参附注射液穴位注射对慢性充血性心力衰竭患者NT-proBNP和6MWD的影响 |
| Effects of Acupoint Injection of ShenFu Injection on NT-pro-BNP and 6MWD of Patients with Chronic Congestive Heart Failure |
| 投稿时间：2016-06-02 |
| DOI：10.3969/j.issn.1673-7202.2017.05.026 |
| 中文关键词: 慢性充血性心力衰竭 参附注射液 穴位注射 |
| English Keywords:Chronic congestive heart failure ShenFu Injection Acupoint injection |
| 基金项目:上海市青浦区科技委员会基金资助项目(编号:青科发2014-05) |
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| 中文摘要: |
| 目的:观察参附注射液穴位注射治疗慢性充血性心力衰竭对患者NT-proBNP、6MWD的影响。方法:将206例符合诊断标准的慢性充血性心力衰竭的患者随机分为对照组和观察组,2组均给予常规治疗:ACEI,不能耐受时使用ARB,β受体阻滞剂选用卡维地洛或者酒石酸美托洛尔,利尿剂选用双克和(或)螺内酯,观察组在此基础上使用参附注射液各2 mL注射足三里和阴陵泉穴,对照组在常规治疗的基础上,使用0.9%NaCl各2 mL,在足三里和阴陵泉穴附近进针,2组疗程均为14 d,隔日1次。治疗前后检测患者心功能、NT-proBNP,进行6 min步行实验(6MWT)。结果:1)观察组与对照组治疗前后6 min步行距离比较差异均有统计学意义(均P<0.05),观察组6 min步行距离改善情况明显优于对照组，差异有统计学意义(P<0.05)。2)心功能临床疗效比较,观察组总有效率为92.3%,对照组总有效率为77.4%,观察组优于对照组,差异有统计学意义(P<0.05)。3)治疗前,观察组NT-proBNP的平均水平为1 973.4 pg/mL,对照组为1 944.6 pg/mL,差异无统计学意义(P>0.05),治疗后,2组NT-proBNP的水平均较治疗前下降(P<0.01),观察组的水平明显低于对照组,差异有统计学意义(P<0.05)。结论:在西医常规治疗的基础上加用参附注射液穴位注射,能提高慢性充血性心力衰竭患者的心功能,降低NT-proBNP的水平,增加6 min步行距离。 |
| English Summary: |
| To observe the effect of acupoint injection of ShenFu Injection on NT-proBNP and 6MWD of patients with chronic congestive heart failure. Methods:Totally 206 cases of chronic congestive heart failure were randomly divided into a control group and a treatment group, given conventional treatment: ACEI, if not then ARB was used, carvedilol or metoprolol tartrate as beta blocker and hydrochlorothiazide and (or) spironolactone as diuretic. The treatment group was provided with Shenfu Injection 2 mL injected at Zusanli and Yinlingquan point on the basis of routine treatment, while the control group using 0.9% NaCl 2 mL, and the course of treatment in the two groups were 14 days, once every other day. Before and after treatment, the patients were tested for cardiac function, NT-proBNP, and 6 min walking test (6MWT). Results:1) The treatment group and the control group's 6MWT comparison before and after treatment showed that there were significant differences (P<0.05) and the treatment group walking distance improvement was better than that of the control group (P<0.05). 2）As to the clinical efficacy of cardiac function comparison, the total effective rate of treatment group was 92.3%, the control group 77.4%, the treatment group better than the control group, and the difference was statistically significant (P<0.05). 3) Before treatment, the average level of NT-ProBNP in the treatment group was 1973.4 pg /mL, control group 1944.6pg/mL, with no statistical significance (P<0.05). After treatment, two groups' NT-proBNP levels were decreased (P<0.01), of which the treatment group was significantly lower than that of the control group (P<0.05). Conclusion:ShenFu injection acupoint injection on the basis of the routine treatment of Western medicine can improve the heart function in chronic congestive heart failure patients, reduce the NT-ProBNP levels and increase 6MWT distance |
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