To observe the efficacy of modified Chaihu combined with Longgumuli decoction on treatment of postmenopausal women with knee osteoarthritis Methods:All 111 diagnosed postmenopausal women with knee osteoarthritis patients were randomized into two groups. The treatment group, 56 cases, were given modified Chaihu combined with Longgumuli decoction, and the control group, 55 cases, took oral administration of western medicine for 14 days. Results: The total effective rate of the treatment group were 92%, the control group 90%. Conclusion:The modified Chaihu combined with Longgumuli decoction may effectively and safely relieve symptoms of the postmenopausal women with knee osteoarthritis.