| 引用本文:王淼，杨盼.异甘草酸镁联合白芍总苷治疗类风湿关节炎并肝功能异常的疗效及对免疫功能和肝功能的影响[J].世界中医药,2017,(05):. |
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| 异甘草酸镁联合白芍总苷治疗类风湿关节炎并肝功能异常的疗效及对免疫功能和肝功能的影响 |
| Efficacy of Magnesium Isoglycyrrhizinate Combined with Total Glucosides of Peony in the Treatment of Rheumatoid Arthritis with Hepatic Dysfunction and Its Effect on Immune and Liver Function |
| 投稿时间：2017-03-24 |
| DOI：10.3969/j.issn.1673-7202.2017.05.033 |
| 中文关键词: 类风湿关节炎 异甘草酸镁 白芍总苷 免疫功能 肝功能 |
| English Keywords:Rheumatoid arthritis Magnesium isoglycyrrhizinate Total glucosides of peony (TGP) Immune function Liver Function |
| 基金项目:河南省自然科学研究计划项目(编号:201310471055) |
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| 中文摘要: |
| 目的:探讨异甘草酸镁联合白芍总苷(TGP)治疗类风湿关节炎(RA)并肝功能异常的临床疗效及对患者免疫和肝功能的影响。方法:选取2015年2月至2016年8月驻马店市中心医院收治的RA患者76例,随机分为观察组和对照组,每组38例,观察组采用异甘草酸镁联合白芍总苷胶囊治疗,对照组采用常规能量合剂治疗,2组均连续治疗14 d。比较2组治疗前后免疫、肝功能及血清RA相关指标变化,并统计不良反应发生情况。结果:治疗后观察组DAS28显著低于治疗前及对照组(P<0.01),晨僵时间、肿胀关节数目、压痛关节数目、握力、HAQ评分2组间差异无统计学意义(P>0.05)。与治疗前比较,治疗后2组患者血清IgE、sIL-2R、ALT、AST水平均降低,且观察组显著低于对照组(P<0.01)。治疗后观察组CRP、TNF-α均显著低于治疗前及对照组(P<0.05或P<0.01)。2组患者均未发生严重不良反应。结论:异甘草酸镁联合TGP能有效改善RA并肝功能异常患者的免疫功能和肝功能,改善RA疾病活动度,且无明显不良反应,值得临床推广应用。 |
| English Summary: |
| To study the clinical efficacy of magnesium isoglycyrrhizinate combined with total glucosides of peony (TGP) in the treatment of rheumatoid arthritis (RA) with hepatic dysfunction and its effect on immune and liver function. Methods: A total number of 76 RA patients with hepatic dysfunction were randomly divided into treatment group and control group, 38 cases in each group. The treatment group was treated with magnesium isoglycyrrhizinate combined with TGP and the control group was treated with conventional energy mixture. Both groups were treated for 14 days consecutively. Changes in immune function, liver function and serum RA were compared before and after treatment, and the incidence of adverse reactions was analyzed. Results: DAS28 in the treatment group was significantly lower than that before the treatment and of the control group (P<0.01). There was no significant difference in morning stiffness time, swelling joints number, tender joints number, grip strength and HAQ score between the two groups (P>0.05). After the treatment, serum IgE, sIL-2R, ALT and AST levels in the two groups were significantly lower and the treatment group was superior to the control group (P<0.01). The levels of CRP and TNF-α in the treatment group after the treatment were significantly lower than those before treatment and in the control group (P<0.05; P<0.01). No serious adverse reaction was detected in the two groups. Conclusion: Magnesium isoglycyrrhizinate combined with TGP may improve the immune function and liver function of patients with hepatic dysfunction and RA activity without obvious adverse reactions, which is worthy of clinical application. |
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