世界中医药

目的:探讨益心舒胶囊对2型糖尿病合并冠心病心绞痛患者的临床疗效。方法:选取2015年3月至2016年1月南阳市第一人民医院收治的2型糖尿病合并冠心病心绞痛患者88例,随机分为对照组与观察组,每组44例,对照组采用常规抗心绞痛及降糖药物治疗,观察组在对照组的基础上加用益心舒胶囊治疗,2组患者均治疗8周。治疗后统计2组患者临床疗效;检测并比较治疗前后2组患者血糖、血脂水平及血小板活化指标水平的变化。结果:与对照组比较,治疗后观察组临床症状改善及心电图改善显效比例及有效率均显著升高,无效比例显著降低(P<0.05或P<0.01);与治疗前比较,治疗后2组患者FBG、2 h PBG、HbA1c及TG、TC、LDL-C水平均明显降低,且观察组显著低于对照组(P<0.05或P<0.01),而2组患者HDL-C水平明显升高,且观察组显著高于对照组(P<0.01);治疗后对照组仅PAC-1及MAR较治疗前有明显降低(P<0.05),而观察组LAP、CD62P、PAC-1及MAR均较治疗前显著降低,且显著低于对照组(P<0.01)。结论:益心舒胶囊可显著改善2型糖尿病合并冠心病心绞痛患者的血糖、血脂水平,明显抑制血小板活化,提高临床疗效。

English Summary:

To study the clinical analysis of Yixingshu capsule in treatment of type 2 diabetes mellitus complicated with angina pectoris due to coronary heart disease. Methods: A total of 88 patients with type 2 diabetes mellitus complicated with angina pectoris due to coronary heart disease were randomly divided into control group and observation group, 44 cases in each group. The control group was treated with conventional anti-angina pectoris and hypoglycemic agent, the observation group was treated with Yixinshu Capsule on basis of the control group, both for 8 weeks. After treatment, the clinical efficacy of the two groups was measured. The levels of blood glucose, blood lipid and platelet activation were measured before and after treatment. Results: The clinical symptoms, the effective rate of ECG and symptom improvement of the observation group were significantly increased compared with the control group and the proportion of ineffectiveness was significantly decreased (P<0.05 or P<0.01). The levels of FBG, 2 h PBG, HbA1c, TG, TC and LDL-C in the two groups were significantly decreased, and the observation group were significantly lower than those in the control group (P<0.05 or P<0.01). The level of HDL-C in the two groups were significantly increased and the observation group was significantly higher than the control group (P<0.01). The levels of PAC-1 and MAR were significantly increased compared with those before the treatment in the control group (P<0.05). The levels of LAP, CD62P, PAC-1 and MAR in the observation group were significantly decreased, and significantly lower than those in the control group (P<0.01). Conclusion: Yixinshu Capsule can significantly improve blood glucose and blood lipid and inhibit platelet activation of patients with type 2 diabetes mellitus complicated with coronary heart disease angina pectoris, improving clinical curative effect.

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