To observe the clinical efficacy of fire needle combined with bloodletting in the treatment of knee osteoarthritis(KOA). Methods:A total of 70 KOA patients in Zhuhai Hospital of Guangdong Province Traditional Chinese Medical Hospital from October 2015 to April 2016 were randomly divided into control group (n=35) and treatment group (n=35). Control group was treated with conventional western medicine (diclofenac sodium enteric-coated tablets) and treatment group was treated with fire needle combined with bloodletting. The changes of TCM symptom score, visual analogue scale(VAS)score, index of severity for osteoarthritis (ISOA), Japanese Orthopaedic Association (JOA) scores and range of motion of two groups before and after treatment were compared to evaluate the clinical efficacy of the two methods. Results:After treatment, TCM symptom score, VAS score, ISOA score of two groups decreased, but JOA knee osteoarthritis score, range of motion increased, and the above indexes of treatment group were better than control group (P<0.05). Total effective rate of the treatment group was 91.73%, which was higher than that of the control group 65.71% (P<0.05). Conclusion:Fire needle combined with bloodletting for treating KOA has high clinical efficacy. It can relieve clinical symptom, reduce pain, accelerate recovery of knee joint function and improve survival quality. Due to its treatment advantages, it is worthy of further application.