To observe the clinical effect of thermal sensitive moxibustion on anemia of cancer and to lay the foundation for the promotion of its clinical application. Methods: Under the patient's informed consent, we selected a total of 65 cases of patients with anemia of cancer, from January 2015 to December 2016 according to the number table and randomly divided them into 2 groups, eliminating 4 cases of shedding, 30 cases in the treatment group, 31 cases in the control group. Two groups were treated with conventional therapy, including: EPO therapy or iron, folic acid, vitamin B12 and other treatment. The treatment group were treated with extra thermal sensitive moxibustion, once per day in the first 3 days, and after that, 3 times per week, for a course of 1 month. Red blood cells, hemoglobin level were evaluated before and after trearment. At the end of treatment and1 month later, MDASI symptom scale was evaluated. Results: After the treatment, f red blood cells and hemoglobin levels of the 2 groups were lower than those before the treatment with statistically significant difference (P<0.05). Comparing the clinical efficacy after treatment, the total efficiency of treatment group was 60%, significantly higher than that of the control group 25.81%, and there was statistically significant difference (P<0.01). As to MDASI scale evaluation, symptom score and life scores of 2 groups were lower than those before treatment, the treatment group better after treatment. One months later after the treatment, discomfort reaction rate of the treatment group was 38.31%, significantly lower than that of the control group 44.37% (P<0.05), and life score was significantly better than that of the control group (P<0.01). Conclusion: Thermal sensitive moxibustion can effectively improve the degree of anemia of cancer and the quality of life of patients, which has good clinical application value.