世界中医药

目的：探讨茵栀黄颗粒治疗新生儿病理性黄疸的临床效果分析。方法：选择2013年5月—2016年2月间在本院出生并接受治疗的病理性黄疸新生儿78例，按照随机数字法，将入组患儿分为：接受常规治疗的对照组40例；接受茵栀黄颗粒治疗的观察组38例，持续治疗7 d。治疗7 d后，比较2组临床疗效、血清胆红素浓度、黄疸消退时间、丙氨酸氨基转移酶（ALT）、总胆汁酸（TBA）、总胆红素（TBIL）和不良反应。结果：治疗7 d后，观察组的治疗总有效率高于对照组（P<0.05）；观察组血清胆红素改善情况显著优于对照组，且黄疸消退时间显著短于对照组：（P<0.05）；观察组ALT、TBA、TBIL含量低于对照组（P<0.05）；治疗期间，2组不良反应总发生率差异均无统计学意义（P>0.05）。结论：茵栀黄颗粒可提升新生儿病理性黄疸的治疗效果，优化血清黄疸相关指标，且具有良好的治疗安全性。

English Summary:

To study the effect of Yinzhihuang Keli?on pathological jaundice of newborn. Methods: A total of 78 cases of newborns with pathological jaundice delivered treated in our hospital during May 2013 to February 2016 were chosen asdivided into control group（n=40） and observation group（n=38） by means of random Numbers . The control group was given conventional treatment; the observation group was treated with Yinzhihuang Keli.After 7 days of continuous treatment, comparison between the two groups was made in terms of clinical curative effect,serum bilirubin concentration, the fading time of jundice, alanine aminotransferase （ALT）, total bile acid （TBA）, total bilirubin （TBIL） and adverse reactions. Results: The total effective rate in observation group was higher than that in control group（P<0.05）; the observation group showed signicantly better effect than the control group as regard to improving serum bilirubin concentration （P<0.05）; fading time of jaundice in observation group was shorter that in control group （P<0.05）;the observation group showed lower level of ALT, TBA, TBIL than the control group （P<0.05）. There was no statistical significance regarding the the difference of adverse reaction incidence between the two group during the treatment period （P>0.05）. Conclusion: Yinzhihuang granules shows desirable effect and safety in improvement of pathological jaundice of the newborns and optimization of relavant indices of serum and jaundice.

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