| 引用本文:刘静1，陆德铭2.不同年龄段和不同转移状态的三阴性乳腺癌患者的临床和病理特征分析[J].世界中医药,2017,(06):. |
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| 不同年龄段和不同转移状态的三阴性乳腺癌患者的临床和病理特征分析 |
| Analysis of Clinical and Pathological Characteristics of Triple Negative Breast Cancer Patients with Different Ages and Different Baseline Metastasis Status |
| 投稿时间：2016-03-22 |
| DOI：10.3969/j.issn.1673-7202.2017.06.065 |
| 中文关键词: 乳腺癌 三阴性乳腺癌 临床特征 年龄 转移 中医治疗 |
| English Keywords:Breast cancer Triple negative breast cancer Clinical characteristic Age Metastasis Chiense Medicine treatment |
| 基金项目:第五批全国老中医药专家学术经验继承班课题,上海市卫生和计划生育委员会中医药继承专项研究课题（编号:2014S25） |
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| 中文摘要: |
| 目的：分析不同年龄段和不同基线转移状态的三阴性乳腺癌患者的临床和病理特征。方法：采用回顾性研究方法，将2010年1月1日至2014年2月28日在上海市中医医院特需门诊就诊的三阴性乳腺癌患者，根据不同年龄段（＜35岁，35～60岁，≥60岁）和不同基线转移状态（有无术后转移）分别进行分组，比较其临床和病理特征以及中医临床表现。结果：共108例三阴性乳腺癌术后患者纳入研究，患者平均年龄47岁，主要接受改良根治术，主要病理类型为浸润性导管癌，36.1%的患者腋下淋巴结阳性，术后转移8例（7.4%）。＜35岁患者较其他年龄段患者更偏向选择保乳术。与没有发生术后转移的患者比较，有术后转移的患者手术次数更多、病理分期更高、接受中医治疗更晚。不同年龄段患者中医临床表现无差异，而基线有术后转移的患者食欲不振、恶心呕吐等胃肠道症状较未发生术后转移患者更常见。结论：不同年龄段和不同基线转移状态的三阴性乳腺癌患者的临床特征有差异，但这些患者的中医临床表现无差异。这些临床和病理特征的差异对长期预后影响尚有待随访观察。 |
| English Summary: |
| To analyze clinical and pathological charateristics of triple negative breast cancer （TNBC） patients with different ages and different baseline metastasis status. Methods:A retrospective cohort study was conducted, in which TNBC patients were grouped according to their ages （younger than 35 years old, 35～60, older than 60） and baseline metastasis status （with or without baseline metastasis）. Clinical and pathological charateristics were compared as well as the clinical symptoms of Chinese Medicine. Results:Among the 108 TNBC patients enrolled, their average age was around 47; most patients received modified radical mastectomy; major pathological type was invasive ductal carcinoma, 36.1% patients showed positive ALN, 8 patients （7.4%） had metastasis after surgery. Patients younger than 35 preferred conserving surgery. Compared with patients without baseline metastasis, patients with baseline metastasis received more surgeries, with higher pathological stages, and later receipt of TCM treatment. There was no significant difference of TCM symptoms among the patients with different ages. Patients with baseline metastasis showed higher rate of anorexia and gastrointestinal symptoms, such as nausea and vomit. Conclusion:There were significant differences of clinical characteristics among TNBC patients with different ages and baseline metastasis status, but no differences on clinical symptoms of TCM. The impact of these clinical differences on long term outcomes needs further follow-up. |
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