To observe the clinical efficacy of Banxia Xiexin Decoction in treatment of disharmony between liver and spleen after colorectal cancer surgery. Methods:A total of 140 patients with disharmony between liver and spleen after colorectal cancer surgery admitted into the hospital from September 2014 to June 2016 were selected as research subjects and were divided into control group (n＝70) and research group (n＝70) by random number table. Patients in the control group took conventional medical treatment, while patients in the research group additionally took Banxia Xiexin decoction on the basis of treatment for the control group. The clinical symptoms, survival quality and carcino embryonic antigen (CEA) level of the two groups before and after the treatment were compared. The clinical efficacy and safety of the two groups were evaluated. Results:The total effective rate of the research group was 90.00% (63/70), which was significantly higher than 71.43% (50/70) of the control group (P<0.05). The TCM symptom score, serum CEA level of two groups significantly decreased after treatment compared with before treatment, but Karnofsky (KPS) score increased. The above indexes of the research group were all better than those of the control group (P<0.05). There was no liver and kidney dysfunction and adverse reactions in both the two groups during the treatment. Conclusion:Banxia Xiexin decoction for disharmony between liver and spleen after colorectal cancer surgery can significantly increase clinical efficacy, relieve clinical symptoms, decrease serum CEA level, promote patients' recovery and improve survival quality, which has significance of clinical promotion.