| 引用本文:宋恩峰1，吴紫红1，梅莎莎1，张彩蝶1，项琼1，裴学军2.健脾生血颗粒治疗肿瘤化疗相关性贫血临床观察[J].世界中医药,2017,(07):. |
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| 健脾生血颗粒治疗肿瘤化疗相关性贫血临床观察 |
| Clinical Observation in the Treatment of Cancer Chemotherapy Related Anemia with Jianpi Shengxue Granule |
| 投稿时间：2017-06-10 |
| DOI：10.3969/j.issn.1673-7202.2017.07.012 |
| 中文关键词: 健脾生血颗粒 肿瘤化疗相关性贫血 重组人红细胞生成素 |
| English Keywords:Jianpi Shengxue Granule Cancer chemotherapy related anemia EPO |
| 基金项目:武汉市科技攻关计划项目(2013070204020053) |
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| 中文摘要: |
| 目的：观察健脾生血颗粒治疗肿瘤化疗相关性贫血的临床疗效及作用机制。方法：将100例符合肿瘤化疗相关性贫血诊断的患者，按随机数字表法随机分为2组，每组50例。2组患者均给予重组人红细胞生成素皮下注射10 000 IU/次，每周3次的基础治疗。治疗组给予健脾生血颗粒口服补铁，15 g/次，3次/d（每天补充铁元素180 mg）；对照组给予硫酸亚铁缓释片口服补铁，0.45 g/次，2次/d（每天补充铁元素180 mg）。2组连续治疗30 d后观察中医证候评分及RBC、Hb、SF、KPS评分等指标变化，并评价有效率与不良事件发生情况。结果：2组患者治疗前各项指标比较无统计学意义（P>0.05），具有可比性。治疗组患者均按医嘱完成治疗，对照组5例患者因为不能耐受消化道不良反应，于治疗1周内退出研究，2组脱落率有统计学意义（P<0.05）。治疗治疗组临床总有效率明显高于对照组（P<0.05）；2组治疗后中医证候评分、RBC、Hb、SF、KPS等指标均有显著改善（P<0.05），且治疗组显著优于对照组（P<0.05）。治疗组不良事件发生率显著少于对照组（P<0.05）。结论：健脾生血颗粒治疗肿瘤化疗相关性贫血疗效显著，安全性、依从性良好，值得临床推广应用。 |
| English Summary: |
| To observe the clinical effect and the mechanism of Jianpi Shengxue Granule on tumor chemotherapy related anemia. Methods:A total of 100 patients who were diagnosed with tumor chemotherapy related anemia were randomly divided into 2 groups. Both of the groups of cases were all treated based on recombinant human erythropoietin subcutaneous injection (hi, 10000IU, 3 times per week). The control group (50 patients) were treated by ferrous sulfate sustained-release tablets (po, 0.45 g, 2 times per day). The treatment group (50 patients) were treated by Jianpi Shengxue Granule (po, 15 g, 3 times per day). Chinese medicine symptom complex score and indexes of RBC, Hb, SF, KPS, etc, were detected after 30 days treatment. Drug effective rate and ADE were also evaluated. Methods:There was no significant difference between the two groups in terms of indexes before the treatment (P>0.05). Patients in treatment group were all treated according to the doctor's advice, while 5 patients in control group withdrew from the study for gastrointestinal ADR within one week. The total effective rate of treatment group was obviously higher than that of control group (P<0.05).The treatment group cases all completed the treatment according to the doctor's advice, whereas 5 cases in control were withdrew from the study because of no toleration of gastrointestinal ADR. The total effective rate of treatment group was obviously higher than that of control group (P<0.05). The indexes of RBC, Hb, SF, KPS, etc, in two groups were all obviously improved than the levels before treatment (P<0.05). And these indexes of treatment group were better than that of the control group (P<0.05). ADE rate of treatment group was significantly lower than that of control (P<0.05). Conclusion:Jianpi Shengxue Granule is effective on tumor chemotherapy related anemia on security and compliance, so it can be used widely in clinical work. |
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