To observe the clinical effect of Yangxinshi Tablets in treatment of ischemic cardiomyopathy complicated with insomnia. Methods:A total of 80 patients with ischemic cardiomyopathy complicated with insomnia were randomly divided into Yangxinshi Group and Control Group, 40 cases in each group. The Control Group received routine therapy, while Yangxinshi Group was given further treatment by Yangxinshi tablets besides routine therapy. Eight weeks made a course. The changes of electrocardiogram, cardiac function classification and sleeping time of the two groups were observed. Results:Compared with the Control Group, the ST segment of ECG recovered obviously (P<0.05), cardiac function classification was increased (P<0.05), and sleep time was prolonged (P<0.05) in Yangxinshi Group. There was statistical significance in comparison between the two groups. Conclusion:Yangxinshi Tablets can obviously improve the symptoms of myocardial ischemia and the classification of cardiac function. Besides, Yangxinshi Tablets are helpful for the insomnia.