世界中医药
文章摘要
引用本文:张晶晶,杨瑞.疏血通注射液对急性心肌梗死患者的疗效及对微循环及血小板状态的影响研究[J].世界中医药,2017,(07):.  
疏血通注射液对急性心肌梗死患者的疗效及对微循环及血小板状态的影响研究
Study of the Clinical Efficacy of Shuxuetong Injection in the Treatment of Acute Myocardial Infarction and the Effect on the Microcirculation and Platelets status
投稿时间:2017-05-25  
DOI:10.3969/j.issn.1673-7202.2017.07.014
中文关键词:  急性心肌梗死  疏血通注射液  心电图  微循环  血小板活化
English Keywords:Acute myocardial infarction  Shuxuetong injection  Electrocardiogram  Microcirculation  Platelet activation
基金项目:郑州市科技攻关计划项目(112PPTSF312-3)
作者单位
张晶晶,杨瑞 郑州大学附属郑州中心医院心血管内科,郑州,450007 
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中文摘要:
      目的:分析疏血通注射液治疗急性心肌梗死(AMI)的临床疗效及对患者微循环及血小板状态的影响。方法:选取2014年12月至2016年1月本院收治的AMI患者98例,随机分为对照组及观察组,各49例,对照组进行常规西医治疗,观察组在对照组的基础上联合疏血通注射液治疗,2组均连续治疗15 d。统计2组临床疗效并比较2组动态心电图变化情况;检测并比较治疗前后2组微循环及血小板活化指标的变化。结果:观察组临床总有效率为95.92%,显著高于对照组的83.67%(P<0.05);与治疗前比较,治疗后2组24 h缺血发作次数及ST段最大下降幅度均明显减少,ST段下降时间明显缩短(P<0.01),且2组间差异有统计学意义(P<0.05或P<0.01);与治疗前比较,治疗后2组管襞畸形率、白微栓率及红细胞聚集率均明显降低,2组襞顶直径明显缩短,管襞数目均明显减少,且2组间差异有统计学意义(P<0.01);与治疗前比较,治疗后2组患者血清CD62p、CD63及GMP-140表达率均明显降低,且观察组显著低于对照组(P<0.01)。观察组不良反应发生率为2.04%,较对照组的14.29%显著降低(P<0.05)。结论:疏血通注射液可显著减少AMI患者心梗频次,减轻其心梗程度,同时可明显抑制患者血小板活化,改善AMI患者微循环,疗效显著优于常规西药单用。
English Summary:
      To explore the clinical efficacy of Shuxuetong injection in the treatment of acute myocardial infarction(AMI)and the effects on the microcirculation and platelets status.Methods:A total of 98 cases AMI patients in our hospital from Dec,2014 to Jan.2016 were selected and randomly divided into control group and treatment group,49 cases for each group,control group was treated with conventional western medicine treatment,while treatment group was treated with Shuxuetong injection on the basis of control group.Both of the groups were treated continuously for 15 days.The clinical efficacy was observed in both of the groups,the changes of dynamic electrocardiogram in 2 groups were compared.The microcirculation in 2 groups was compared with before; platelet activation markers in 2 groups was also detected and compared with that before the treatment.Results:The clinical total effective rate of treatment was 95.92%,which was higher than that 83.67% in control group(P<0.05);Compared with the situation before the treatment,the attack times of 24 h ischemia and the maximal ST-segment depression decreased significantly,the time to ST segment depression reduced significantly(P<0.01),and the difference between 2 groups was significant(P<0.05 or P<0.01); the tube fold deformity rate,microembolus rate and erythrocyte aggregation rate in 2 groups decreased significantly comparing with before the treatment,the diameter of fold the top shortened; the number of tube fold in 2 groups decreased significantly,and the difference between 2 groups was significant(P<0.01).The expression rates of CD62p,CD63 and GMP-140 in 2 groups decreased significantly,and the expression rates in treatment group were much lower than those in control group(P<0.01).The incidence of adverse reactions of treatment group was 2.04%,lower than that of control group(14.29%,P<0.05).Conclusion:Shuxuetong injection can reduce the frequency of myocardial infarction of AMI patients,alleviate the degree of AMI,furthermore,it can restrain the platelet activation effectively and improve the microcirculation of AMI patients.The clinical efficacy of Shuxuetong injection is significantly better than conventional western medicine only.
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