To explore adjuvant effect of Fuzheng Xiaoliu Decoction for chemotherapy on tumor markers and immunity of postoperative breast cancer patients. Methods:A total of 74 breast cancer patients were selected and divided into treatment group and control group according to the random numbers generated by computer, with 37 cases in each group. The two groups were treated with conventional chemotherapy, while treatment group additionally treated with Fuzheng Xiaoliu Decoction. Levels of tumor markers, immunity and the scores of Functional Assessment of Cancer Therapy-Breast Quality of Life Instrument (FACT-B) in the two groups before and after the treatment were compared. Results:The levels of serum CEA, CA125, CA153, TSGF, VEGF-A, IGF-1 and TK1 in the treatment group after the treatment decreased significantly compared with those before the treatment (P<0.05 or P<0.01). The proportion of CD3+, CD4+ in the control group decreased significantly after the treatment. The proportion of CD3+, CD4+ and CD4+/CD8+ increased significantly and the proportion of CD8+ decreased significantly in the treatment group (P<0.05 or P<0.01), with significant difference between the two groups (P<0.05 or P<0.01). The proportion of NK cell had no significant difference (P>0.05). The FACT-B scores in the treatment group after the treatment increased significantly and were higher than those in the control group (P<0.01). Conclusion:Fuzheng Xiaoliu Decoction adjuvant to chemotherapy can improve immune function of patients with breast cancer, reduce levels of serum tumor markers, enhance life quality of breast cancer patients and reduce postoperative recurrence or metastasis to some extent.