To observe the clinical effect of therapy of regulating metal activities and qi on menopause syndrome (MPS). Methods:A total of 120 patients meeting the diagnostic criteria were divided into three groups. The Chinese medicine treatment group (40 patients) was given therapy of regulating metal activities and qi. The Chinese medicine control group (40 patients) was given Zhibai Dihuang Pill or Yougui Pill. The control group (40 patients) was given with Tibolone Tablets. Patients in the three groups were treated for three months. The improvement of the kupperman score and the variation of their FSH and E2 in the blood serum were compared. Results:The kupperman score of the three groups all decreased after the treatment (P<0. 05). The kupperman score of the treatment group was superior to the Chinese medicine control group with the similar effect to that of the control group (P>0. 05), significantly better than the Chinese medicine control group (P<0. 05). There was no significant difference in FSH between the comparison before and after treatment in the three groups (P>0. 05). Serum E2 of the control group was significantly increased (P<0. 01). The total effective rate was 100% in the Chinese medicine treatment group and the control group, significantly better than the Chinese medicine control group (P<0.05). Conclusion:Therapy of regulating metal activities and qi can obviously improve the kupperman score of the patients with MPS, but have no effect on the Serum E2 and FSH.