| 引用本文:周绵莉，毛惠，喻小兰.妇科千金片联合克罗米芬治疗多囊卵巢综合征合并不孕的疗效观察[J].世界中医药,2017,(07):. |
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| 妇科千金片联合克罗米芬治疗多囊卵巢综合征合并不孕的疗效观察 |
| Curative Effect of Gynecologic Qianjin Tablets Combined with Clomiphene of Treatment in Polycystic Ovarian Syndrome with Infertility |
| 投稿时间：2017-05-05 |
| DOI：10.3969/j.issn.1673-7202.2017.07.017 |
| 中文关键词: 妇科千金片 克罗米芬 多囊卵巢综合征 不孕 炎性反应 氧化应激反应 |
| English Keywords:Gynecologic Qianjin table Clomiphene Polycystic ovarian syndrome Infertility Inflammatory Oxidative stress reaction |
| 基金项目:四川省中药管理局课题(2016c045) |
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| 中文摘要: |
| 目的:观察妇科千金片联合克罗米芬治疗多囊卵巢综合征(Polycystic Ovarian Syndrome,PCOS)合并不孕的疗效及对炎性反应及氧化应激反应的影响。方法:选取2014年1月至2016年6月西南医科大学附属中医院收治的PCOS合并不孕患者96例,随机分为观察组和对照组,每组48例,对照组给予克罗米芬治疗,观察组在对照组基础上给予妇科千金片治疗,疗程为3个月经周期。观察2组治疗前后临床症状体征、卵巢变化、机体性激素水平、月经恢复、排卵及妊娠情况;记录2组治疗前后炎性反应及氧化应激反应相关指标的变化。结果:观察组治疗后体质量指数(BMI)、腰臀比(WHR)、多毛评分及卵巢体积均较治疗前显著降低(P<0.05),观察组改善情况均显著优于对照组(P<0.05);2组治疗后血清睾酮(T)、促黄体生成素(LH)、促卵泡刺激素(FSH)以及LH/FSH比值均显著降低,观察组上述指标均低于对照组(P<0.05);观察组治疗后月经恢复情况、宫颈黏液评分、子宫内膜厚度、排卵及妊娠率均优于对照组、流产率低于对照组(P<0.05)。2组治疗后血清白细胞介素-6(IL-6)、白细胞介素-17(IL-17)、超氧化物歧化酶(SOD)活性、谷胱甘肽过氧化物酶(GSH-Px)和丙二醛(MDA)水平均显著改善,观察组改善情况优于对照组(P<0.05)。结论:妇科千金片联合克罗米芬治疗能够显著PCOS患者的临床症状体征,调节机体性激素,并促进排卵及妊娠,其机制可能与抑制机体炎性反应及氧化应激反应有关。 |
| English Summary: |
| To observe the curative effect of Gynecologic Qianjin tablets combined with clomiphene of treatment in polycystic ovarian syndrome(PCOS)with infertility and its effects on inflammatory and oxidative stress reaction.Methods:A tatal of 96 cases of PCOS with infertility patients were randomly divided into observation group(48 cases)and control group(48 cases).Control group was given clomiphene while Observation group was in treatment of Gynecologic Qianjin tablets on the basis of control group,treatment of three menstrual cycles.Observe two groups before and after treatment of clinical symptoms and signs,ovarian change,the body's sex hormone levels,menstrual recovery,ovulation and pregnancy;Records in the two groups before and after the treatment of inflammatory reaction and oxidative stress related indicators of change.Results:Observation group after treatment of body mass index(BMI),waist hip ratio(WHR),hairy score and ovarian volume were significantly lower than before treatment(P<0.05),improve observation group were significantly better than the control group(P<0.05);The two groups after treatment serum testosterone(T)and luteinizing hormone(LH),promote the follicle-stimulating hormone(FSH)and LH/FSH ratio are significantly reduced,the observation group are lower than the control group(P<0.05);Observation group menstruation recovery after treatment,cervical mucus score,endometrial thickness,ovulation and pregnancy rate were better than the control group,the abortion rate is lower than the control group(P<0.05).The two groups after treatment serum interleukin 6(IL 6)and interleukin-17(IL-17),superoxide dismutase(SOD)activity and glutathione peroxidase(gsh-px)and malondialdehyde(MDA)level were significantly improved,the observation group to improve the situation is better than that of control group(P<0.05).Conclusion:Daughter of department of gynaecology piece of joint g 'Finn treatment can significantly clinical signs and symptoms of PCOS patients,regulate the body's sex hormone,and promote the ovulation and pregnancy,the mechanism may be related to suppress the inflammatory reaction and oxidative stress reaction. |
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