| 引用本文:张利云，刘利利，王伟.止喘灵注射液雾化治疗慢性阻塞性肺疾病急性加重期疗效观察[J].世界中医药,2017,(07):. |
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| 止喘灵注射液雾化治疗慢性阻塞性肺疾病急性加重期疗效观察 |
| Clinical Observation on Atomized Zhichuanling Injection for the Treatment of 60 Cases with Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
| 投稿时间：2017-03-06 |
| DOI：10.3969/j.issn.1673-7202.2017.07.020 |
| 中文关键词: 止喘灵注射液 慢性阻塞性肺 急性加重期 临床疗效 |
| English Keywords:Zhichuanling injection Chronic obstructive pulmonary disease Acute exacerbation Clinical curative effect |
| 基金项目:开封市科学技术科研项目(2016D029) |
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| 中文摘要: |
| 目的:观察止喘灵注射液雾化治疗慢性阻塞性肺疾病急性加重期患者的临床疗效。方法:随机选取2016年1月1日至2017年1月1日,于开封市第二人民医院呼吸科住院部就诊的COPD急性加重期患者60例,根据随机数字表法分为观察组和对照组,每组30例.对照组COPD急性加重期的基础治疗,常规抗炎、平喘化痰、吸氧等。观察组在对照组基础上予以肌肉注射止喘灵注射液2 mL,2次/d,连续用药7 d。进行临床疗效评估和BODE多维评价系统评估患者生命质量,治疗前后采血检测WBC(白细胞)、hs-CRP(超敏C反应蛋白),并采用流式细胞仪检查辅助性T细胞17(Th17)。结果:观察组显效率(70.00%)明显高于对照组(50.00%)(P<0.05);治疗后2组组BODE多维评分系统评分明显降低,观察组降低程度明显优于对照组(P<0.05)。与治疗前比较,2组COPD患者治疗后WBC和hs-CRP的表达均显示下降(P<0.05);治疗后观察组WBC和hs-CRP的表达均比对照组低(P<0.05)。以全血制备流式细胞仪样本,经流式细胞仪检测显示,观察组治疗后CD4+IL-17+T细胞百分率为(0.94±0.21)%,显著低于对照组的(2.57±0.47%),组间比较差异有统计学意义(t＝4.11,P=0.002)。结论:止喘灵注射液可明显缓解COPD急性发作症状,其作用机制与Th17细胞密切相关,为指导临床治疗提供参考。 |
| English Summary: |
| To observe the clinical curative effect of atomized Zhichuanling injection for 60 patients with acute exacerbations of chronic obstructive pulmonary disease. Methods:Sixty inpatient cases of acute exacerbation of COPD who had treatment in Department of Respiration of the hospital were selected from January 1, 2016 to January 1, 2017and randomly divided into the observation group and the control group, with 30 cases in each group. Patients in the control group received conventional anti-inflammatory and anti-asthmatic expectorant treatment, oxygen absorption etc., while patients in the observation group additionally received intramuscular injection of 2 mL Zhichuanling injection, twice a day, with 7-day successive treatment. Clinical curative effect was evaluated and BODE multidimensional evaluation system was used to evaluate the quality of life of patients before and after treatment. Blood samples were collected to detect WBC (white blood cells) and hs-CRP (high sensitivity C reactive protein), and flow cytometry was used to detect the T helper 17 (Th17). Results:The effective rate of the observation group (70%) was significantly higher than that of the control group (P<0.05). After the treatment, the BODE scores of the two groups were significantly lower, but more obvious in the observation group (P<0.05). The expression of WBC and hs-CRP in the two groups of patients with COPD were decreased, compared with those before the treatment (P<0.05) and the expression of WBC and hs-CRP in the observation group were lower than those in the control group (P<0.05). In the preparation of whole blood flow cytometry samples by flow cytometry, the percentage of CD4+IL-17+T cells (0.94±0.21)% of the observation group after the treatment was significantly lower than that of the control group (2.57±0.47%), showing that there was significant difference between the groups (t=4.11, P=0.002). Conclusion:Zhichuanling injection can significantly relieve the symptoms of acute exacerbations of COPD and the mechanisms is closely related to Th17 cells, which may provide reference for guiding clinical treatment. |
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