世界中医药

目的:探讨金匮肾气丸辅助治疗对支气管哮喘缓解期患者免疫功能的影响。方法:选取2013年7月至2016年4月在北京积水潭医院接受治疗的支气管哮喘缓解期患者110例,回顾治疗方案并分为接受单纯西医治疗的对照组58例、接受金匮肾气丸辅助西医治疗的观察组52例。治疗前后,比较2组患者的外周血Th17/Treg细胞比例,血清中Th1/Th2细胞因子及体液免疫指标含量的差异。结果:治疗前,2组患者外周血中Th17/Treg细胞比例,血清中Th1/Th2细胞因子及体液免疫指标含量的差异无统计学意义(P>0.05)。治疗后,观察组患者外周血中Th17细胞比例、Th17/Treg比值低于对照组患者,Treg细胞比例高于对照组患者;血清中白细胞介素-2(IL-2)、干扰素γ(IFN-γ)的含量高于对照组患者,白细胞介素-4(IL-4)、白细胞介素-5(IL-5)的含量低于对照组患者;血清中体液免疫指标免疫球蛋白E(IgE)、补体C3的含量低于对照组患者(P<0.05)。结论:金匮肾气丸辅助治疗可优化成人支气管哮喘缓解期患者的细胞免疫、体液免疫功能,具有积极的临床意义。

English Summary:

To study the influence of Jinkuishenqiwan adjuvant therapy on immune function in adult bronchial asthma in remission stage patients.Methods:One hundred and ten cases of adult bronchial asthma in remission stage patients in our hospital during July 2013 to April 2016 were chosen as research subject,treatment methods were reviewed and all patients were divided into control group(n＝58)underwent normal western medicine treatment only,observation group(n＝52)underwent Jinkuishenqiwan adjuvant therapy plus normal western medicine treatment.Before and after treatment,peripheral blood Th17/Treg cell ratio,serum Th1/Th2 cytokines and humoral immune indexes between two groups were compared.Results:Before treatment,there were no significant difference between two groups about peripheral blood Th17/Treg cell ratio,serum Th1/Th2 cytokines and humoral immune indexes(P>0.05).After treatment,Th17 cells and the ratio of Th17/Treg in observation group in peripheral blood were lower than those in control group,Treg cells was higher than that in control group; serum contents of IL-2,IFN-γ were higher than those in control group,IL-4,IL-5 were lower than those in control group;serum contents of humoral immunity indexes such as IgE、C3 were lower than that in control group(P<0.05).Conclusion:Jinkuishenqiwan adjuvant therapy can relieve the cellular immunity,humoral immune function in patients with optimization of adult bronchial asthma,has positive clinical significance.

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