Abstract:To study Shugan decoction in compensatory cirrhosis(CC) and its effects on HA,LN and PC Ⅲ.Methods:All 156 patients with CC who were treated from September 2015 to October 2016 in the hospital were enrolled in this study.According to the simple digital random table method,they were randomly divided into an observation group and a control group,each 78 cases.The two groups were given comprehensive treatment of liver protection,enzyme reduce and jaundice relieving drugs,and the control group was given lamivudine.The observation group was treated with Shugan powder decoction.After 1 month of treatment,HA,LN,PC Ⅲ,portal vein diameter,spleen thickness,and hepatitis B virus DNA (HBVDNA) quantification as well as adverse reactions in different stages( before and 30 d after treatment )of both groups were compared.Results:The total effective rate of the observation group was 96.15%,significantly higher than that of the control group of 87.18%,and the difference was statistically significant (P<0.05).After treatment,the levels of HA,LN and PC in the two groups were significantly lower than before treatment,and the observation group after treatment of LN,HA and PC Ⅲ levels were significantly lower than the control group,and the difference was statistically significant (P<0.05).The diameter of portal vein,spleen thickness and HBVDNA of the two groups after treatment were significantly less than those before treatment,and the diameter of portal vein,spleen thickness and HBVDNA in the observation group were significantly less than those in the control group,with statistically significant difference (P<0.05).The incidence rate of adverse reactions in the observation group was 2.56%,significantly lower than that of the control group of 10.26%,and the difference was statistically significant (P<0.05).Conclusion:The curative effect of CC patients were treated with Shugan decoction is obvious and can significantly improve the level of HA,LN and PC Ⅲ,with favorable liver protection function high safety,which is worthy of promotion.