To analyze the clinical effect of Muli powder and Shengmai decoction on patients with dual deficiency of Qi and Yin type of hyperthyroidism as well as liver function. Methods:A total of 60 cases diagnosed of dual deficiency of Qi and Yin type of hyperthyroidism admitted into our hospital from January 2015 to December 2016 in our hospital were selected, then randomly divided into two groups, with 25 cases in each. The control group was given Hyperthyroidism Ling capsule and the observation group was given Muli powder and Shengmai decoction for 2 months. The clinical efficacy, serum FT3, FT4, TSH levels and liver function indexes (ALT, AST,-GT, TBIL) of the two groups were observed and compared. Results:The total effective rate of the observation group (92.00%) was slightly greater than that of the control group (80.00%), and there was no significant difference between the two groups (P>0.05). After treatment, FT3, FT4, ALT, AST,-GT, TBIL gamma level of the two groups decreased, while the level of TSH increased, the difference was statistically significant (P<0.05). FT3, FT4, ALT, AST in observation group after treatment were lower than those of the control group, and the difference was statistically significant (P<0.05). After treatment, TCM syndrome score of the treatment group was (1.28±0.65) points, slightly lower than that of the control group, without statistical difference (P>0.05). Conclusion:Muli powder and Shengmai Decoction can effectively treat patients with dual deficiency of Qi and Yin type of hyperthyroidism. It can also improve thyroid hormone levels and liver function of patients.