To study the effect of aconite-cake-partitioned moxibustion on angiogenesis in rats with endometriosis. Methods:The rats were randomly divided into control group, model group, moxibustion Group and Dalazol group. Rats in the four groups received treatment for 14 days and samples were made to detect the expression of ang-1 and ang-2 by western blotting assay. Results:Compared with the control group, the ang-1 expression in the model group, moxibustion group and Dalazol group were significantly increased (P<0.05). Compared with the model group, the ang-1 expression in the moxibustion group and Dalazol group were slightly decreased, but without significantly difference (P>0.05). Meanwhile, the expression of ang-2 in the model group, moxibustion group and Dalazol group were significantly increased (P<0.05), compared with the control group. The expression of ang-2 in the moxibustion group and Dalazol group were significantly decreased, compared with model group (P<0.05). Conclusion:Aconite-cake-partitioned moxibustion on CV4 can treat endometriosis by decreasing the expression of ang-2 and inhibiting the angiogenesis.