| 引用本文:覃肯1，罗薇絮2，王萍1，肖小文1，周志刚3.隔药饼灸对子宫内膜异位症大鼠新血管生成的影响[J].世界中医药,2017,(07):. |
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| 隔药饼灸对子宫内膜异位症大鼠新血管生成的影响 |
| Effect of Aconite-cake-partitioned Moxibustion on Angiogenesis in Rats with Endometriosis |
| 投稿时间：2016-06-21 |
| DOI：10.3969/j.issn.1673-7202.2017.07.036 |
| 中文关键词: 子宫内膜异位症 隔药饼灸 Ang-1 Ang-2 |
| English Keywords:Endometriosis Aconite-cake-partitioned moxibustion Ang-1 Ang-2 |
| 基金项目:江西省教育厅科技项目(GJJ11550) |
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| 中文摘要: |
| 目的:探讨隔药饼灸对子宫内膜异位症大鼠血管生成的影响。方法:将大鼠分为空白对照组、隔药饼灸组、西药组以及模型对照组,分别进行相应处理,14 d后处死,检测实验各组标本的Ang-1和Ang-2的表达。结果:与正常组比较,模型组、艾灸组和达那唑组大鼠的Ang-1表达均相对升高(P<0.05),与模型组比较,艾灸组和达那唑组大鼠Ang-1表达有所降低,但差异无统计学意义(P>0.05),与正常组比较,模型组、艾灸组和达那唑组大鼠的Ang-2表达显著升高(P<0.05),与模型组比较,艾灸组和达那唑组大鼠Ang-2表达显著降低(P<0.05)。结论:隔药饼灸可能通过促进降低Ang-2的表达,抑制血管异常增生而达到治疗子宫内膜异位症目的。 |
| English Summary: |
| To study the effect of aconite-cake-partitioned moxibustion on angiogenesis in rats with endometriosis. Methods:The rats were randomly divided into control group, model group, moxibustion Group and Dalazol group. Rats in the four groups received treatment for 14 days and samples were made to detect the expression of ang-1 and ang-2 by western blotting assay. Results:Compared with the control group, the ang-1 expression in the model group, moxibustion group and Dalazol group were significantly increased (P<0.05). Compared with the model group, the ang-1 expression in the moxibustion group and Dalazol group were slightly decreased, but without significantly difference (P>0.05). Meanwhile, the expression of ang-2 in the model group, moxibustion group and Dalazol group were significantly increased (P<0.05), compared with the control group. The expression of ang-2 in the moxibustion group and Dalazol group were significantly decreased, compared with model group (P<0.05). Conclusion:Aconite-cake-partitioned moxibustion on CV4 can treat endometriosis by decreasing the expression of ang-2 and inhibiting the angiogenesis. |
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