| 引用本文:王田，赵慧辉，邓冬，王宏亮，李雪丽，刘婧玮，商晓迪，蔡榕琪，马雪玲，王伟.自发性高血压大鼠肝火亢盛证的认知功能变化[J].世界中医药,2017,(07):. |
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| 自发性高血压大鼠肝火亢盛证的认知功能变化 |
| Research on the Cognitive Function of Spontaneously Hypertensive Rats of Liver-fire Hyperactivity Type |
| 投稿时间：2017-05-03 |
| DOI：10.3969/j.issn.1673-7202.2017.07.038 |
| 中文关键词: 自发性高血压大鼠 肝火亢盛证 认知功能 情绪 |
| English Keywords:Spontaneously hypertensive rats Liver-fire hyperactivity syndrome Cognitive function Emotion |
| 基金项目:国家重点基础研究发展计划(973计划)项目资助(2011CB505106);国家自然科学基金青年项目（81503382）;国家自然基金面上项目（81473521）;北京中医药大学中青年教师项目（面上项目）（2015-JYB-JSMS036） |
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| 中文摘要: |
| 目的：评估自发性高血压大鼠（SHR）肝火亢盛证的认知功能变化，为进一步深入研究高血压认知功能改变的机制及中医药防治奠定基础。方法：采用经典Morris水迷宫和跳台实验，评估肝火亢盛证SHR大鼠的认知功能变化，对照组采用WKY大鼠和Wistar大鼠2种。结果：Morris水迷宫空间探索实验中，穿越平台次数肝火亢盛证SHR大鼠明显少于Wistar组（P<0.05）。跳台实验中，肝火亢盛证SHR大鼠跳上时间明显较WKY组延长（P<0.05），潜伏期则较WKY对照组明显缩短（P<0.05），错误次数较WKY组及Wistar显著增多（P<0.05）。结论：肝火亢盛证SHR大鼠的学习认知功能较WKY及Wistar对照组下降，主要表现为注意力和学习效率下降，受到紧张、愤怒等情绪刺激时判断力下降，且注意力和学习效率下降更为明显。 |
| English Summary: |
| To evaluate the cognitive function of spontaneously hypertensive rats (SHR) of liver-fire hyperactivity type，thus laying the foundation for further research on the mechanism of the cognitive function changes as well as the prevention and treatment of traditional Chinese medicine.Methods:Using the method of classical Morris water maze and step-down test to evaluate the changes of cognitive function of liver-fire hyperactivity SHR rats.The control group use WKY and Wistar rats.Results:In the morris water maze spatial probe test,the time of crossing the platform of liver-fire hyperactivity SHR rats was significantly reduced than that of the control group (Wistar P<0.05).In the step-down test,the reaction time of liver-fire hyperactivity in SHR rats was significantly longer than that of WKY control group (P<0.05),and the latency of liver-fire hyperactivity SHR is significantly shortened than that of WKY control group (P<0.05).Besides,the frequency of mistakes of liver-fire hyperactivity SHR were significantly increased than that of WKY and Wistar control group (P<0.05).Conclusion:Cognitive function of liver-fire hyperactivity in SHR decreased compared with WKY and Wistar control group,mainly manifested as decreased of attention and learning efficiency.When SHR rats were affected by emotions such as tension and anger,the judgment of SHR decreased significantly,and the decrease of attention and learning efficiency was more obvious. |
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