To establish the simple type of allergic rhinitis model and the complex type of kidney yang deficiency of allergic rhinitis model,and to study the different effects of Xiaoqinglong decoction on the two models of allergic rhinitis,evaluating the difference functions of correcting the imbalance of Th1/Th2.Methods:The simple type of allergic rhinitis model was induced with ovalbumin (OVA) in guinea pigs.Based on this,the complex type of kidney yang deficiency of allergic rhinitis model was established with hydroxyurea administration.Both of the two models were evaluated by observing the weight，survival state and local allergic reaction of guinea pigs,testing the contents of INF-γ,IL-4,IL-2 and IL-10 cytokine in serum by ELISA (enzyme-linked immunosorbent assay),and carrying on real-time fluorescence quantitative PCR method for measuring the relative content of IFN-γ mRNA,IL-4 mRNA,T-bet mRNA and GATA-3 mRNA in spleen tissue.Results:In all models,IFN-γ was reduced,IL-4 increased and the ratio of IFN-γ/IL-4 reduced.In the simple type of allergic rhinitis model,Xiaoqinglong decoction could increase IFN-γ and reduce IL-4,increasing the ratio of IFN-γ/IL-4.As to the complex type of kidney yang deficiency of allergic rhinitis model,the effect on IFN-γ was not obvious.Xiaoqinglong decoction could reduce the IL-4 so that the ratio of IFN-γ/IL-4 of both was reduced,as well as IFN-γ mRNA and IL-4 mRNA was increased.Xiao Qinglong decoction could increase IFN-γ mRNA and decrease IL-4 mRNA in both Simple type of allergic rhinitis model and complex type of kidney yang deficiency of allergic rhinitis model,so that it made the ratio of IFN-γ mRNA/IL-4 mRNA increased,and the role in simple type of allergic rhinitis model was more obvious.Both the simple type of allergic rhinitis model and the complex type of kidney yang deficiency of allergic rhinitis model were found T-bet mRNA decreased,GATA-3 mRNA increased,and the ratio of T-bet mRNA/GATA-3 mRNA decreased.Xiaoqinglong decoction could increase T-bet mRNA and reduce the GATA-3 in the simple type of allergic rhinitis model and thus the ratio of T-bet mRNA/GATA-3 mRNA was increased.In the complex type of kidney yang deficiency of allergic rhinitis model,Xiaoqinglong decoction had no obvious effect on T-bet mRNA,but it also could reduce the GATA-3 mRNA,increasing the ratio of T-bet mRNA/GATA-3 mRNA.Conclusion:Xiaoqinglong decoction can significantly improve the local allergic reaction of the simple type of allergic rhinitis model,but has relatively small effect on the complex type of kidney yang deficiency of allergic rhinitis model.Xiaoqinglong decoction regulates the balance of Th1/Th2 by increasing the ratio of IFN-γ mRNA/IL-4 mRNA and T-bet mRNA/GATA-3 m RNA.Also,it has more obvious effect on the simple type of allergic rhinitis model.