To study clinical curative effect of single thumb massage, plucking reinforcement technique combined with acupotomy in the treatment of knee osteoarthritis. Methods:A total of 60 cases of knee joint osseous arthritis patients who came to Beijing Hospital of TCM from April 2015 to March 2016 were randomly divided into two groups, of which the observation group was of 30 cases, using single thumb massage, plucked reinforcement technique twice a week combined with acupotomy once a week, to do a knife a week for 2 times, each time 15 minutes, for five weeks as a course of treatment; and the control group of 30 cases and applied with intra-articular injection of Carboxymethylchitin every 2 weeks and massage twice a week, each time 15 minutes, for five weeks as a course of treatment. All patients had curative effect evaluation after 6 weeks of treatment. Results:The statistical analysis results showed that in the observation group, patients’ overall efficiency rate was 93.3%, and in the control group 80.0% (P<0.05). After 2 weeks, 4 weeks of treatment, patients of the observation group had lower score in symptoms of pain, stiffness, and joint function, which is better than those of the control group (P<0.05). The observation group’s patients recovered better than the control group with higher score of physiological function, physiological function, health status and energy and lower score of body pain (P<0.05). The patients’ quality of life in the observation group were better (P<0.05). Conclusion:Single thumb massage, plucking reinforcement technique combined with acupotomy can significantly improve not only the symptoms and signs of osteoarthritis of the knee but also the quality of life of patients with knee osteoarthritis, which is an effective treatment method with important clinical value.