To learn clinical effect of acupuncture exercise therapy on patients with knee osteoarthritis and on joint function. Methods:In total, 95 patients with knee osteoarthritis hospitalized from January 2015 to July 2015 were divided into a treatment group (acupuncture exercise therapy group) of 35 cases, a control group 1 (dynamic interference with microwave treatment group) of 30 cases and a control group 2 (common acupuncture treatment group) of 30 cases, observing their improvement of symptoms. Results:In 35 cases of the treatment group, clinical recovery accounted for 51.43%, effective 8.57%, markedly effective 34.29%, only 2 cases ineffective, accounting for 5.71%, the effective rate was as high as 94.29%. In the control group 1 of 30 patients, only 5 cases fitted the clinical recovery criteria, accounting for 16.67%, and effective rate 23.33%, markedly effective 26.67%, 10 cases ineffective, and the total effective rate was only 66.67%. In control group 2 of 30 patients, 33.33% recovered, 23.33% effective, 26.67% markedly effective, 16.67% ineffective, the total effective rate was 83.33%. Comparison between acupuncture exercise therapy group and control group 1 showed a clear difference (P<0.05); while between acupuncture exercise therapy group and control group 2, there is no difference (P>0.05), but had statistical significant in markedly effective rate (P<0.05), with satisfactory clinical results. Comparing MOWAC scale scores in each group, before treatment the pain, stiffness, function score by t test was found(P>0.05). After the treatment of pain, stiffness, function before and after comparison of scores were significant (P<0.05), acupuncture exercise therapy group better than the control group. Conclusion:Acupuncture exercice therapy can significantly relieve symptoms of knee osteoarthritis patients, improve knee function and daily living and quality of life with a good prospect.